The effect of aqueous extract of Foeniculum vulgare seeds on soom electrolytes in serum of white male rat induced by inflammation of the kidneys

Abstract

This study aimed to find out the effect of the warm aqueous extract of seeds fennel on white male rats infected kidney inflammation induced glycol ethylene.The study was conducted at the animal house of the college of pharmacy/ University of Kerbala for the period from November 2015 to March 2016. A number of 75 white male rats were taken as a sample and randomly divided into five groups ( 15 rats for each group ). The first group was the negative control group which was given tap water for a period of 45 days. The second group received glycol ethylene with a concentration 0.75% was given with water and considered as a positive control group; while the third, fourth, and fifth groups were induced by kidney Inflammation of treating glycol ethylene. The rats were orally given and after days of Inflammation induction of kidney by seeds fennel aqueous extract with doses of 50, 100, and 150 mg/kg of body weight per day for a month successively .Blood samples were collected from both groups before the induction of kidney inflammation and after 15 days of induction of kidney inflammation and month after the dosage aqueous extract seeds plant fennel to study Almaiaralaty :measure the level of sodium (Na+) and measure the level of Potassium (K+) and measure the level of calcium (Ca2+) and measure the level of Magnesium (Mg+) and measure the level of Chloride (Cl-) and measure the level of Phosphate (Po4) in the blood as well as taking other textile segments of the liver, kidney, heart, and for the purpose of studing the histological changes after measuring the weights of these members , showed the results of the current studyThe results of the study . said the induction of kidney inflammation in male albino rat led to a significant increase (P<0.05) in the Sodium (Na+) level and Potassium (K+) and Calcium ( Ca+2) and Magensium (Mg+2) and Chloride (Cl-) and Phosphate Po4 compared with healthy control , and obtain a significant decrease (P<0.05) in the Sodium level and Potassium K+ and Magensium Mg+2 and Chloride Cl- and phosphate Po4 and Calcium Ca+2) in the treatment of aqueous extract fennel seeds plant as compared to the infected control totals