Study Effects of Oral Contraceptive on Some hormones hematological Parameters and Testis of Experimental Male Rat

Abstract

AbstractOral contraceptive, Birth control, pills are mainly used to prevent the pregnancy. Thecombination of progesterone and estrogen are commonly use in these days. In this paper, we aimedto determine the influence of progesterone and estrogen as synthetic chemical found in oralcontraceptive pills on male rats. we investigated the contribution of oral contraceptive on 2 groups ofmale rats. 25 and 50mg/kg a had been given through gavage for 60 days. Level of testosteronealsowere measured utilizing Minvids. Determination of red blood cells, RBCs, total white blood cellsand platelets PLwhere been counted using coulter counter. There was a significant influence of oralcontraceptive pills on WBC and PLT while there are not significant effect of RBC comparing to thecontrol. Moreover, in the current study level of Testosterone was not significantly affected due totreatments comparing to the control in both groups. Eosin and Hematoxylin stain used to makehistological sections of testiest and the results showed that normal spermatogenesis can be seenclearly in the control group after 60 days’ exposure. The spermatogenesis is disrupted based on dosewhere 50mg of oral contraceptive exposure showed very high level of disturbance. Reductions in thenormal designand abnormal distance in seminiferous tubules also noticed after 60 day’s treatmentwith oral contraceptive. In addition to reduce the number of germ cells and somatic cells populationafter 50mg exposure are counted in high level of contraceptive taken.