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Association of Seminal Plasma Level of NLRP3 Inflammasome Protein with Quality of Seminal Fluid Parameters Among Infertile Men

Hussain Kh. Kadhem --- Ula A. AL-Kawaz --- Haider F. Ghazi --- Nuha A. Younis

Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم
ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2018 Volume: 8 Issue: 2 Pages: 36-42
Publisher: Al-Nahrain University جامعة النهرين

Abstract

Background:inflammasome protein govern the inflammatory process. The elevationof NLRP3 inflammasome might be related to bad seminal fluid analysisresults.Objectives:This study aimed to evaluate seminal plasma NLRP3 protein and itsrelation with seminal fluid analysis parameters before and after in vitro spermactivation.Patients and Methods: a total of 50 infertile patients were collected form higherinstitute of infertility diagnosis and assisted reproductive technique, there semensamples were processed for seminal fluid analysis before and after in vitrosperm activation. NLRP3 inflammasome protein were measured in seminal plasma.Results:the mean level of NLRP3 protein was 5.12 ng/ml. the higher level ofNLRP3 protein (4.5ng/ml) associated with lower sperm concentration, grade A,B, C and higher level of grade D motility. However, 50% of those patients havean improvement in their seminal fluid analysis after in vitro sperm activation.Conclusion:Elevation of NLRP3 protein in seminal plasma may be associatedwith the increased leukocytospermia, bad sperm quality and unresponsiveness toin vitro sperm activation among infertile male.

Keywords

NLRP3 --- Inflammasome --- Seminal fluid analysis and Infertility