Determination of Captopril Drug capotine Pharmaceutical Product by Molecular Absorption Technique

Abstract

Extraction of the drug Captopril from capotine (angiotensin converting enzyme inhibitors (ACE inhibitors) with hot water was studied .Reaction of Captopril with Cu2+ ion was also studied and found to forms a complex [(3-Mercapto -2- methyl – propionyl)] - L – proline copper (II). The new analytical methods based on measurement the molecular absorbance in UV-Visible Spectrum at λ max=760 nm. Optimum pH and divalent copper ion concentration were estimated. Linearity (0.50-0.78g/dl), detection limit 0.35g/dl, relative standard deviation %RSD (2.13%) were determined. The complex is identified with UV-Visible and IR spectra. The mole ratio also investigated and found 1:2(Cu2+ : Captopril).