EFFECT OF POLICOSANOL EXTRACT ADMINISTRATION ON LIPID PROFILE IN HYPERCHOLESTROLEMIC FEMALE RATS DURING LACTATION

Abstract

The present study designed to investigate the effects of the extracted policosanol on lipidprofile of hypercholestrolemic lactating female rats (Ratus norvigicus). Forty eight female rat(10-12) weeks old,and weighting (200-250 gm) were used in the current study. After dailyvaginal smear for 3 sequences estrus cycles, they mated with twenty four healthy adult fertilemales weighting (280-350 gm), 24 of these females were induced to be hypercholestrolemicduring the pregnancy,and others still healthy. Sugarcane were collected from Mesan provinceand policosanol was extracted from sugarcane wax. Immediately after birth the animals weredivided into 6 groups: Group 1 (n=8) (Control) : Normal rats were given only 0.5 ml/ animal ofDimethyl Sulphoxide (DMSO) daily immediately after birth. Group 2 (n=8) hyperchol. (HC):Hpercholestrolemic rats were given only DMSO 0.5 ml/ animal daily immediately after birth.Group 3(n=8) (HC+SM): Hpercholestrolemic rats were given simvastatine at dose 20mg/kgBW/ day dissolved in DMSO orally by gavages' immediately after birth. Group 4(n=8) (SM) :Normal rats were given only simvastatine at dose 20mg/kg BW/ day dissolvxsqqs ed inDMSO orally by gavages' immediately after birth. Group 5 (n= 8) (HC+ST. pol):Hpercholestrolemic rats were given standard policosanol at dose 20mg/kg BW/day orally bygavages' immediately after birth. Finally group 6(n=8)( HC+EX. pol): Hpercholestrolemic ratswere given policosanol extraction at dose 20mg/kg BW/day orally by gavages immediatelyafter birth. The treatment continued until weaning ( 30 days).