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The analgesic activity of Mentha piperita (MP) leaves extract

الفعالية التسكينية لخلاصة أوراق النعناع

Ahmed Najim abed saleh احمد نجم عبدالله صالح

The Iraqi Journal of Veterinary Medicine المجلة الطبية البيطرية العراقية
ISSN: 16095693 Year: 2010 Volume: 34 Issue: 2 Pages: 73-78
Publisher: Baghdad University جامعة بغداد

Abstract

In the present work, the antinociceptive action was assayed in several experiment models in mice, Hot plate, writhing and formalin test. The alcoholic extract of MP leaves at a dose of 150mg/kg B.W and 300 mg/kgB.W showed antinociceptive effects in different methods, where the dose of 300 mg/kg B.W showed significant reduction of the nociception by acetic acid. In the formalin test, the extract (300mg/kg B.W) also significantly reduced painful stimulus in both phases of the test. Treatment with extract (300mg/kg B.W) when given orally produced significant increase of the reaction time in hot plate test. These results showed that the leaves extract of MP contain active analgesic principles acting both centrally and peripherally.

Keywords

analgesic --- menthe piperita --- leaveextract.