Fulltext

Local Expression of MMP-7 in Oral Cancer

Manal A. Habib منال حبيب

Al-Kindy College Medical Journal مجلة كلية الطب الكندي
ISSN: 18109543 Year: 2011 Volume: 7 Issue: 1 Pages: 14-17
Publisher: Baghdad University جامعة بغداد

Abstract

Background: Squamous cell carcinoma of the oralcavity (OSCC) is a highly invasive neoplasm. ManyMMPs play role in human cancer invasion andmetastases.Aim: Estimating The MMp-7 expression level inHPV-16 positive and HPV-16 negative OSCCparaffin embedded sections.Method: Biopsies from thirty three patients with oralsquamous cell carcinoma (OSCC) were obtained andinvestigated for the presence of HPV-16 RNA withthe application of ISH and the MMP-7 expressionlevel using IHC .Results: Expression level of MMP-7 found to be highin OSCC sections 29 (87.8%) cases with nosignificant difference in its expression level betweenHPV-16 positive and HPV-16 negative OSCC casesp= 1.00.Conclusion: MMp-7 found to be expressed in highlevel in OSCC with no significant relevance to HPV-16.

Keywords

oral squamous cell carcinoma --- HPV-16