Preparation and in vitro Evaluation of Ketoprofen Solid Dispersion System

Abstract

For poorly soluble drugs, such as ketoprofen, the rate of oral absorption is often controlled bythe dissolution rate in the G.I.T. Therefore the solubility and dissolution behavior of a drug iskey determinants of its oral bioavailability. Several formulations of liquisolid capsulescontaining two ratios of ketoprofen: Vehicles (1:1 and 1:2) were prepared. In this study theratio of microcrystalline cellulose (carrier) to silica (coating powder) was 20:1 for allformulations and then changed to 10:1. The dissolution behavior of ketoprofen from liquisolidcapsules and conventional capsule formulation was investigated at two different pHs (1.2 and6.8). The x-ray diffraction ( XRD )of solid dispersion of ketoprofen in ratio of 1:1 wascharacterized to ascertain if there were any physicochemical interactions between the drugand carrier that could affect dissolution.The results showed that liquisolid capsulesdemonstrated considerably higher dissolution rate than those of conventionally madecapsules. This could be attributed to increased wetting properties and surface of drugavailable for dissolution. XRD showed a change in crystal structure toward an amorphousform of ketoprofen.