Measurement of protein and creatinine levels in serum and urine of cadmium exposed rabbits

Abstract

Measurement of protein and creatinine levels in serum and urine of cadmium exposed rabbitsH. A. Al-AbassColl. of Vet.Med./Unive. of Al-QadisiyaAbstractMale rabbits were exposed to cadmium during 16 weeks by subcutaneous injections of 0.25mg cadmium Cd (CdCl2) per kg B.W.3times per week, Creatinine in serum ,Cd in blood as well as total protein, Creatinine ,Cd in urine were determined before exposure and after 3,7 weeks of exposure.Measurments were also made at 19 weeks, 3 weeks after the last exposure. During exposure there was slight increase in total protein/Creatinine ratio among rabbits with the highest exposure ,while no effect of the cadmium burden could be observed once exposure had ceased.Urinary excretion of total protein was related to urinary pH in the high exposure group, significant increase in urine total protein excretion indicative of renal tubular dysfunction was seen after 7 weeks of exposure .This was ,however not related to serum total protein level.It was concluded that before renal damage has occurred even heavy cadmium exposure has very little influence on serum total protein level.