Abstract

Recent studies have highlighted on association between anemia and the development andprogression of diabetic nephropathy. There is also an increased cardiovascular risk in patients withdiabetic nephropathy and a clear association between anemia and abnormal cardiac function,although most patients in the previous studies have type 2 diabetes mellitus. The present studyfocused on the possible variations in hematological parameters as well as hs-CRP levels in anemictype 1 and type 2 diabetics without microalbuminuria, in relation to their glycemic indices.The study groups compromised of 50 diabetic patients (25 with type 1 and 25 with type 2) whohad been selected to have haemoglobin levels below the gender specific normal range with negativemicroalbuminurea, in comparism to two control groups of 16 and 18 healthy subjects,respectively,whom are age and sex matching of type 1 and type 2 patients.For this the patientsblood specimens were taken for testing blood levels of haemoglobin, red blood cellscount,reticulocyte count, Hb A1C levels; as well as fasting serum glucose, serum insulin, C-reactiveprotein levels.The results indicated that anemia in both types of diabetes was not related to any of the RBCindices(MCV, MCH, MCHC), results are not shown, but it s related to lowered total number ofRBC as compared to their controls. Meanwhile,their was no evidence of an increased reticulocyte inthe studied groups of either types of diabetes, indicating a defective erythropoiesis rate, although theselected patients were without detectable nephropathy (ve testing for microalbuminuria).Furthermore, the reduction in RBC count was not significantly correlated with glycemic indices(FPG, FPI, HbA1C, QUICKI). However, hs-CRP levels were significantly elevated in diabeticpatients, but CRP levels were significantly correlated with fasting serum insulin in type 2diabetics,but not in type1. Which may indicate a role for inflammation in type 2 diabetes incontribution to insulin resistance that may provide an additional risk factor for cardiovasculardiseases in this type of diabetic whom have anemia as well.

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The article was added to IASJ on 2012-05-31

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