Synthesis and antibacterial evaluation of Some Pyrano-1,3-- Oxazine Derivatives

Abstract

AbstractSome dipeptide amide and amino derivatives of 7-chloro-4,5-dioxopyrano [3,4-e]-l,3-oxazine, compounds (2a-d) and (3a-e) respectively have been synthesized and studied against five species of bacteria in vitro. A significant activity against staph. Aureus and Bacelus Subtilis were observed by the above derivatives at concentration ranging from (0.1-10 mg./ml.) and remarkable activity was exhibited by 2-(N-glycyl glycine amido)-7-chloro-4,5-dioxopyrano [3,4-e]-l,3-oxazine (2a). Other compounds showed no significant activities. The I.R. and NMR spectral data of the synthesized compounds were also discussed and are included.