Determination of some polyamines in serum of breast cancer patients

Abstract

In this study, serum polyamine (spermidine & spermine) levels were measured in 28 breast cancer patients and compared with 25 healthy controls. Blood samples obtained from two groups (control & patients) and quantitative determination of polyamine were determined by using High Performance Liquid Chromatography (HPLC). It was found that spermidine is significantly increased (p<0.05) in patients levels was observed when breast cancer patient compare with normal subjects, and significantly increase than the healthy control population to the spermine with (p<0.05).