Synthesis and evaluation of Biological activity of new cyclic Imides derived from 4-amino phenazone

Abstract

A series of new cyclic imides containing phenazone heterocycle were prepared via following three different methods.The first one involved direct reaction of different cyclic anhydrides with 4-amino phenazone producing the corresponding amic acids which subsequently introduced in dehydration reaction to afford the desirable imides while the second method involved treatment of 4-amino phenazone with chloro acetyl chloride affording 4-(2-chloro acetamido) phenazone which introduced in reaction with potassium salts of both phthalimide and succinimide producing N-(2-acetamido phenazone -4-yl)phthalimide and succinimde respectively .The third method involved reaction of 4-(2-chloro acetamido) phenazone with N- ( hydroxy phenyl) phthalimides producing three new N-(oxy acetamido phenazone-4-yl) phenyl phthalimides.Antibacterial activity of the prepared new imides against two types of bacteria were evaluated and the results showed that the new imides exhibit good to moderate antibacterial activity. Antifungal activity of the new imides were also tested against candida albicans fungi and most imides showed slight activity against this fungi.