MUTAGENIC EFFECTS OF FLUORINE GIVEN BY DRINKING WATER ON THE CHROMOSOMAL ABERRATION AND MICRONUCLEI IN WHITE MICE MALE

Abstract

The present experiment was designed to study the mutagenic effects of fluorine given by using NaF in drinking water on the chromosomal aberration (CA) and Micronuclei (Mn) in white mice male for three month. (65) male mice divided into three groups the 1st and 2nd groups daily intake (150 and 300 ) mg/L NaF indirectly by drinking water give NaF, while give tap water to the control group. The cytogenetic analysis showed that NaF was causes significant increased (P≤0.01) in M.n and C.A which include “break, ring, delayed and gap” so concluded that fluorine toxicity has dose related effects.