Synthesis, Characterization and Antimicrobial Activityof 3-substituted Benzo[4,5]thiazolo[2,3-c][1,2,4]triazole

Abstract

Abstract:New series of tricyclic benzo[d]thiazole derivatives (2-12) incorporated into fused todifferent five membered nitrogen and sulphur containing heterocyclic were prepared from 2-hydrazinobenzo[d]thiazole (1) when treated with triethylformate, acetic anhydride, ethylchloro acetate, carbon disulphide in alkali, and urea respectively.Compound(1) converted to Schiff’s bases by the condensation different aromaticaldehydes, the synthesized Schiff’s bases were cyclized by bromine in acetic acid to formtriazole ring in the new derivatives (7-11) , which might result in biologically active agents.Similar new tricyclic compounds, triazolobenzothiazol-3-amine [12], was obtained fromaction of benzo[d]thiazole-2-thiol with thiosemicarbazide. The structures of the newcompounds have been characterized by elemental analysis and spectral data.Newly synthesized compounds (2-12) were screened for their antibacterial activityagainst four bacterial species. They were found to exhibit good antibacterial activity.