The Effect of Therapeutic Lactic Acid Bacteria on Some Intestinal Diseases induced by Salmonella enterica serovar typhimurium in Female Rats

Abstract

The study was conducted to isolate and identify Lactic acid bacteria from dairy products, which were later used as probiotic and determination its oral adminstration with isolated bacteria for 7 days as a challenge to Salmonella enterica serovar typhimurium (STM) infection and compairing that with ciprofloxacin as an antibiotic . Ten isolate were isolated which belongs to Bifidobacterium and Lactobacillus.Two species of isolated Lactobacillus L. bulgaricaus and L. delbrueckii were used as a probiotics , feeding single oral dose of one daily numbers of 1.3 × 108 cells / ml, while rat pathogenic isolates bacteria (STM) and the same numbers, and compared with antibiotic with two concentration 0.5 and 1.0 mg / ml.The results showed after first day from feeding the positive impact of the two types of bacteria effective in the treatment of Salmonella infection, butter than the antibiotic suggestion the efficiency of the using of these types as probiotic.