The Correlation Between Blood Glucose Level and Lipid Profile in Hypothyroid Diabetic Patients in Baghdad

Abstract

Abstract:The objective of this study was to investigate the effects of thyroid hormonesdisorders on serum lipid profile among the hypothyroidism diabetic patients. For this purposeblood samples were collected randomly from (40) subjects with hypothyroidism (TSH> 5 mIU/L, T4 < 50 n mol/L) (male and female) from the endocrine center of Al-Yarmook teachinghospital in the age range of (30- 65) years. Included (21) diabetic patients who had thyroiddysfunction (hypothyroidism) according to clinical examinations and laboratory results, (werechosen as case group) and the remaining (19) subjects were consider as control group.The following variables were measured: Fasting serum glucose, thyroid hormones(T3, T4 and TSH) and lipid profiles (total cholesterol, low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol (HDL-C), Very Low density lipoprotein VLDLand triglycerides (TG)).The statistical analysis of results of this study revealed a significant correlationbetween fasting serum glucose (FSG) with severity of thyroid hormones disorders levels (T3,T4 and TSH), beside significantly increased serum total cholesterol (include HDL, LDL andVLDL) and triglyceride (P. value < 0.05) with hyperglycemia.We conclude that hyperglycemia is associated with significant changes in lipid profileand thyroid hormones level in hypothyroid-diabetic patient as compared with non diabeticcontrol group with negative correlations.