In vitro and In vivo Effect of Myrtus communis Extracts on Staphylococcus aureus Isolated from Patients with UTI

Abstract

Urinary tract infection (UTI) defines as a condition in which the urinary tract is infected with different pathogens as Staphylococcus aureus (S. aureus) causing inflammation. This study was "carried out to evaluate the in vivo and in vitro effect of Myrtus communis (M. communis) plant extracts on S. aureus isolated from UTI. This study included 350 patients (125 males and 225 females) with signs and symptoms of UTI, who were referred to the Teaching Hospital in Erbil and Sulaimania cities, from March till May 2007. Also, 25 healthy individuals were included in the study as a control group. Agar well and disc diffusion assay were used for in vitro test while 3 groups of rats were used for in vivo test. The bacterial cultivations revealed positive results for 119 (34%) urine specimens; 56 (47.05 %), 63 (52.94 %) and 0 (0%) in males, females and control group respectively. The rate of uropathogenic S. aureus was 23(17.82%). Ethanol extract of M. communis was the most efficient to inhibit S. aureus in vitro and in vivo.