In vivo immunohistochemical investigation of the effect of the topical application of growth hormone on the osseointegration of cpTi implant

Abstract

Background: Dental implants are a suitable option for the replacement of some or all missing teeth. The successfulinsertion of a biocompatible material into living tissue with little to no evidence of rejection has revolutionizedmedicine and dentistry. An increase in bone response was observed with local administration of growth hormonearound dental implants. Growth hormone may act as a bone stimulant in the placement of endosseous dentalimplants and enhances osseointegration. The aim of the study was to evaluate immunohistochemically the effect ofthe topical application of growth hormone on the osseointegration of cpTi implant.Materials and Methods: Eighty titanium screw implants were inserted in the tibia of the forty adult rabbits. Growthhormone was applied on experimental implants. Immunohistochemical tests were performed on the implants of bothcontrol and experimental groups for (3 days1, 2, and 6 weeks) healing intervals.Results: Titanium implants coated with growth hormone revealed an early bone formation, minerlization andmaturation in comparison to control. Immunohistochemical findings revealed positive expression for VEGF inexperimental implant in comparison to control one.Conclusion: Topical application of growth hormone may act as a bone stimulant in the placement of endosseousdental implants and enhances osseointegration