Evaluate the Activity of Cucumis melo Ethanol Extract against Skin Cancer Named Melanoma


Chinese medicine herbs have a large library of bioactive compounds and Cucumis melo is one of Chinese herbs has been used for medical treatment and exhibit anticancer activity against colon cancer. In the present study, we evaluate anticancer activity of Cucumis melo ethanol extract at first by using high throughput screening HTS for herb fractions screening in concentration of 100μM to identify the effective fraction and then we measured the cytotoxic effects by using morphology changes, and detect apoptosis by AO/EB staining, our results showed that Cucumis melo ethanol extract have a strong toxicity against human melanoma A375 cancer cells and requires more investigation to identify the small natural molecule who is responsible for this cancer activity.