Biological Activity of Thiazole Derivatives on SomePathogenic Microorganisms

Abstract

The thiazole derivatives were prepared by the reaction of benzaldehyde derivatives with
(2-thiooxamide-5-(p-bromobenzene)-1,3-thiazole) that was readily prepared by heating
dithiooxamide with 4-bromophenacylbromide. Within invitro study the the effect of the prepared
compounds on the growth of two types of fungi geotrichum cadidum and Trichophyton rubrum and
the bacteria Escherichia coli, pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiella
pneumoniae was evaluated. Incubation time and concentration were studied to find the optimal
conditions for the activity. Compound II with the concentration 20 mg/ml found to be the most
active compound toward geotrichum and Trichophyton rubrum. Statistical analysis of the values of
colonial diameter shows low percentage error for the studied fungi with regard to incubation time.