The Effect of Alcoholic Extract of Citrullus colocynthus in Testicular Function of Adult Male Albino Rats.

Abstract

The Effect of Alcoholic Extract of Citrullus colocynthus in Testicular Function of Adult Male Albino Rats.B. D. I. Al-WataarColl. of Vet. Med./ Univ. of MosulAbstractThe present study conducted to determine the effect of different doses (100, 200 and 300 mg / kg of body weight) of alcoholic extract of bitter melon in the functions of the testis. The results of the current study, showed these doses have caused a decrease in concentration of the testosterone compared with the control group, as well as the increase in the level of cholesterol, in addition to gross changes an increaseing in the size andcongestion of testis from mild to severe, compared with control group, in addition to necrosis and destruction in the cells of Leydig cells, which ranged also from the simple to the broad and destroy the spermatocytes and sperm and desquamation in the lumen of seminephrous tubules, and these lesions suited with dose given to male rats. Conclude from this study that the dose of 300 mg/kg of body weight of alcoholic extract of bitter melon have had the biggest impact on the functions of the testis to have had the impact in a significant decrease in the concentration of the testosterone, and increase in the concentration of cholesterol, also an increase in weight of testis, with testicular congestion and severe destruction of leydig cells with necrosis and desquamation of spermatocytes and sperm in the lumen of seminepherous tubule.Keyword: Citrullus, Testosterone, Cholesterol, Male rats.