Study the histological changes in kidney by different doses of vitamin C in rabbits

Abstract

Study the histological changes in kidney by different doses of vitamin C in rabbitsS. D.A. Al-Gnami I. A. Al-AtharyColl. of Vet. Med. /Univ. of Al-Qadisiya AbstractThis study carried out in animal house in medicine collage in al-kofa university ,there are 32 local rabbits were used which ranged between(11-12) months in age, and (1100-1600) gm in weight ,all rabbits was femal only.The animals were divided into four equal groups , each group contain 8 animals, the first one leaved as control and the others drenched by 7,14 and 21 mg of vitamin C for each Kg.B.W. daily for 3 weeks, and the management conditions are similar in all groups.The results of the microscopic study show the presence of many of the histological changes as a result of treatment with vitamin and found dilation of renal tubules and small glomeruli when dosage the animals with 7 mg / kg of vitamin C, as results showed the sever dilation in the renal tubules with the survival of glomeruli are normal, as well as to the presence hemorrhage in the kidney tissue at the dosage of animals with 14 mg / kg of the vitamin, as the results indicate the emergence of necrosis and expanded greatly in tubules kidney for females with deposit of hyaline with vitamin C concentration of 21 mg / kg with the appearance of cloudy swelling in renal tubules and the lumen appear star shape, stars with get destroyed in the glomeruli.