Correlation Between Glucose – 6 – Phosphate Dehydrogenase Deficiency Level and Some Haematological Parameters on Newborn Blood in Al-Anbar Governorate-Ramadi

Abstract

This study aimed to determine the prevalence of Glucose-6-PhosphateDehydrogenase (G6PD) deficiency in Al-Anbar Governorate-Ramadi and tostudy the different relationships between these cases and differenthaematological parameters values. In addition to that this study aimed toinvestigate the degree of G6PD deficiency in both sever and moderate status andto find the ratio of this enzyme deficiency in both sexes .One hundred sixty six(166) samples from both sexes (80) males and (86) females(neonates) werecollected.Results showed that the overall frequency among neonates of G6PDdeficiency was 10.84% (13.75% males and 8.13% females.Significant differencein G6PD deficiency was found between both sexes, males showed morefrequency than females (P< 0.01.) Males showed high ratio of acute G6PDdeficiency than females (P< 0.01), vise versa for the moderate G6PD deficiency.The normal G6PD activity level, mean ± standard deviation among neonates was(10.85±0.88) IU/gm.Hb.,this mean activity value was(9.77±0.82)IU/gm.Hb.for males and (11.93±0.95)IU/gm.Hb.for females, while thisvalue among neonates with G6PD deficiency was (1.59±0.120)IU/gm.Hb.,formales (0.98±0.063)IU/gm.Hb.and (2.21±0.187)IU/gm.Hb. for femalesrespectively.Patients with G6PD deficiency neonates showed significantly lower(P< 0.01) haemoglobin (Hb), packed-cell volume (PCV), red blood cell count(RBC) and enzymatic activity values than G6PD normal subjects.WhileReticulocyte count was higher in the samples of neonates with G6PD deficiencybut this increase was not significant in comparison to the normal neonates. (P>0.05)Also non significant differences (P> 0.05) were found between samples ofnormal individuals and those of G6PD deficiency regarding white blood cellcount (WBC) .