Obesity and lipid profile in type 2 diabetics

Abstract

This case-control study includes 356 diabetics and 384 apparently healthy age and sex
matched controls who attended Al-Zahrawi Private Hospital Outpatient Department in Mosul
during the period from January to December 2004.The aim of the study was to assess the changes
in serum lipid profile among type 2 diabetics in relation to body mass index (BMI) and to determine
the magnitude and pattern of dyslipidaemia in obese diabetics. Fasting plasma glucose and serum
lipid profile were compared in type 2 diabetics and control subjects according to BMI. The
collected data were analyzed by chi-square, Z, ANOVA and Duncan tests. Fasting plasma glucose
levels were highest in obese diabetics and the frequency of poorly controlled diabetics was
increased with increasing BMI. There was a significant and positive association between the BMI
and serum triglyceride (TG) (p 0.01), total cholesterol (TC) (p 0.001), LDL-C (P<0.001) and
VLDL-C (P<0.01). Serum HDL-C levels were significantly decreased (P<0.01) by increasing
BMI. The prevalence of dyslipidaemia was increased with increasing BMI levels in both genders.
In conclusion several lipid abnormalities in type 2 diabetics have pointed to the significance of
diabetic control, regular lipid profile and control of obesity.