التوصيلية الكهربائية للمضادات الحيوية الاموكسيسيلين ، التراي ميثيوبريم والايزونازايد في محيط مائي وفي درجات حرارية مختلفة

Abstract

AbstractThis research is the electrical Conductivity study for each of trimetheprim, amoxicillin trihydrate and isoniazid in conductivity water at different temperatures (288.15-313.15) Kelvin By using lee-Wheaton equation for symmetrical electrolytes (1:1), The conductivity parameters have been calculated. The equivalent conductivity at infinite dilution (). The ion pair association constant (KA) and the mean distance values between ion (R) at the best value of standard deviation (). It is found that the values of () and (R) for each drug increase with increasing temperature, while the values of KA are inversely proportional with temperature. By comparing these values, They follow the sequence: o: amoxicillin trihydrate < trimetheprim < ioniazedKA : isoniazid < trimethoprim < amoxicillin trihydrateR : ionized > trimethoprim > amoxicillin trihydrateAn accurate method for determination of these drugs by using conductometric titration method with hydrochloric acid and sodium hydroxide have been found to be good and sensitive comparing with (the standard addition and potentiometric titration methods) from encyclopedia.