دراسة كيميائية حياتية عن الثايوسيانيد وعلاقته بمرضى الفشل الكلوي

Abstract

The research, involved determination of thiocyanate concentration and some of biochemical changes in renal failure compared with normals. The result demonstrated a significant increase in the level of (thiocyanate , creatinine ,urea , Uric acid ) and a significant decrease in the level of (total protein ,globulin) in renal failure patients compared with control, while non significant increase of albumin in patient compared with control.According to sex, it had been found that females have higher concentration of thiocyanate than male in renal failure patients as well as controls, and there was no relation between thiocyanate concentration and the age. The result also demonstrated a significant increase of thiocyanate in smokers compared with non smokers in two groups, patients and control. While a significant increase of thiocyanate was observed in samples with taken acyanogenic plant compared with its non taken acyanogenic plant in patients and control. Correlation coefficients between thiocyanate and biochemical changes of renal failure patients showed that thiocyanate has negative linear relationship with total protein , and a positive linear relationship with (albumin, creatinine, urea) in renal failure patients.