Spectrophotometric Determination of Promethazine Hydrochloride by In (111) .

Abstract

A simple, vapid and sensitive spectrophotometirc metho) determination of trace amounts of promethazine hydrochloric aqueous solution is described. The method is based on complication of promethazine hydrochloride with In(Ill) in presence of sodium hydroxide to form an intense product maximum absorption at 304nm. Beer's law is obeyed over concentration range of (2-20ug/m1) with molar adsorptively The optimum conditions for (5.006x 10 3 L.mol-1 .cm-1 ).development are described and the proposed method has successfully applied for the determination of promote hydrochloride in bulk drug.