Levels of Interleukin-2 in Iraqi Patients Serum with Angina Pectoris

Abstract

Abstract Recent findings suggest that inflammation and cytokines regulation may play a role inthe pathogenesis of atherosclerosis and ischemic heart disease. So the aim of present studywas conducted to obtain more clarifications about the role of interleukin (IL) -2 whichconsidered as regulatory cytokine on the clinical expression of Angina Pectoris among Iraqi patients. Materials & Methods: Serum levels of (IL-2) were measured in 70 Iraqi patients with Angina pectoris: 40 with unstable angina, 30 with stable angina, beside 20 healthyvolunteers as control group. Enzyme Linked Immunosorbent Assay (ELISA) technique has been applied for (IL-2) estimation.Results & Conclusions: The results of present study revealed that there is a significant increase in (IL-2) level among the sera of angina (62.8±15.3pg/ml) in comparison with (39.8±5.1pg/ml) of healthy control group, with highly significant differences between patients with unstable angina and stable angina disease.It was concluded that proinflammatory cytokine (IL-2) may play an important role in the development of disease and its complications in other words of IL-2 in unstable angina may suggest additional immunologic activation.