Sy rrth esis of New 4,5-di hydro- 1 H-i m idazole-2-thiol Derivatives

Abstract

In this wOrk, 4,5-dihydro… lI―I_ilnidazole-2-thiol was prcparedfrom ethylene diarnine and then converted into 2「hydrazino_4,5-dihydro-lH― imidazOle(2),Mannich bases(3-5),4,5-dillydro-lH_imidaz01e-2-ylamino)thiO]aCedc acid (6), 2-alkyithiO-4,5-dihydro-lH― imidazOles(7 and 8),2-(-4,5‐dihydro-lH_imidaをol_2-yl― thiO) aCetalnide (9), 2-[o対ran_2-ylmethy)thiO]- 4,5-dihydro-lH― imidazOle(10),6,7‐ dihydro_5H_iidazO[2,1_c][1,2,4-]triaZole_3-aminc (11) and azOmethines (12-14). Hcazomethines(12-14)were converted tO [1_aCetyl‐2-(4,5-di hydro- 1 H -imidazol-2 -yl) hydrazinel (4 -bromophenyl )methylacetate (15), 2-(4-aminOphenyl)_3-(4,5-dillydrO_lH_imidazol -2-yl am ino -2- m ethyl - 1,3 -th iazo I i ne_4 _one( I 6) _a!d_N