The prevalence of Von-¬¬¬Willebrand disease in menorrhagia and post partum hemorrhage

Abstract

Objective: To estimate the prevalence of Von-Willebrand disease in women with menorrhagia and post partum hemorrhage. Patients & method: It is a cross sectional study done in the department of obstetrics and gynecology in Al Yarmouk teaching hospital from 1st of October 2004 to 30th of October 2005.Ninety nine women participated in this study. Thirty nine women with menorrhagia,30 women with post partum hemorrhage and 30 women as control. Blood sample from each case was drawn for von Willebrand factor antigen (vWf-Ag), factor 8(fvIIIc), prothrombin time (P.T.), activated partial thromboplastine time (APTT),bleeding time, C.B.P, renal function test and liver function test. Laboratory results for menorrhagia and post partum hemorrhage patients were compared with those of control group to estimate the prevalence of von Willebrand disease.Results: Von-Willebrand disease was found in five(12.8%), four (13.3%)and zero(0.0%)from women with menorrhagia, post partum hemorrhage and control groups respectively.Conclusion: The measurement of the laboratory investigations for Von- Willebrand factor should be incorporated into the diagnostic evaluation of patients referred to gynecological clinic with menorrhagia or post partum hemorrhage of certain criteria, otherwise; it may lead to hemorrhagic complications associated with surgical intervention in patients with Von- Willebrand disease.Key wards: Von-Willebrand disease, menorrhagia, post partum hemorrhage.