Effect of Clomiphene citrate on the levels of some hormones parameters of male and female albino Rabbits

Abstract

This study involved giving the administration of clomiphene citrate to albino Rabbits through the feeding tube .Was used in this experiment (24) Rabbit were distributed randomly into five groups . Group is control to each containing (8) animals (4 males and 4 females), second group to each containing (4 females) , third group to each containing (4 male) treated with (2mg kg clomiphene citrate) , four group to each containing (4 females) , and five group to each containing (4 male) treated with (4mg kg clomiphene citrate) .Were in this study investigate the effective of the clomiphene citrate drug on fertility and to its effect on the Follicular Stimulating Hormone (FSH) , Luteinizing Hormone (LH), Prolactin, Testosterone in both sexes .The study results showed the following: that giving the animals ( male and female) a dose (2mg kg) resulted in this treatment to raise the concentration of the hormone FSH and LH rise was not significant for both sexes, either treatment dose (4mg kg) has led to raise the concentration hormone level (P ≤ 0.05) for both sexes compared with the control group. There is also a significant difference in the concentration of hormone Testosterone and prolactin in both sexes compared with the control group as a result treatment dose (2, 4 mg kg). has resulted in treatment B (2mg kg) to raise the concentration hormone Testosterone and prolactin increase was not significant for males, as to the concentration of both hormone in females has resulted in treatment to reduce the concentration hormone decrease was not significant compared with the control group. either treatment (4mg kg) led to the lifting of concentration hormones increase significantly for males either for females, there was a significant decrease in the concentration of hormones compared with the control group.