Spectrophotometric Determination of Sulfacetamide in Pure Form and Pharmaceutical Formulations with Metol and potassium hexacyanoferrate (ΙΙΙ)

Abstract

Abstract:A simple, sensitive and accurate spectrophotometric method ofdetermination of Sulfacetamide (SAC) in pure form and pharmaceuticalformulation.The method is based on the formation of (SAC) complex. The reactionbetween of the Sulfacetamide with the mixture of metol and potassiumhexacyanoferrate (ΙΙΙ) was evaluated for the spectrophotometric determination ofthe Sulfacetamide. The maximum absorbance of the colored complex occurred atλ=540nm. Reaction conditions have been optimized to obtain (SAC) complex ofhigh sensitivity and longer stability. Under optimum conditions the absorbance ofthe (SAC) complex where found to increase linearly with increase in concentrationof the Sulfacetamide, which corroborated with correlation coefficient value. Theconcentration ranges are 0.1-100 μg ml-1 with detection limit 0.01842μg ml-1 and