Salivary and seral sex steroid hormones variation among group of peoples with gingivitis

Abstract

Background: This study aimed to determine the level of sex steroid hormones (estradiol, testosterone) in the sera andsaliva of the patients and controls, also to establish the type of correlation between the change in the biochemicalinflammation markers (ALP, C-RP, IL-6, ALb) and levels of sex hormones (estradiol, testosterone) in gingivitis patientsand control.Sample and Methods: The work included ninety samples (serum and saliva) of 45 volunteers (22males & 23females),twenty one patients with gingivitis and twenty four healthy subjects as control group.Results: the results showed a highly significant increase (p<0.001) in IL-6 for male in serum and saliva samples whilesignificant increase (p<0.05) for females And a highly significant increase (p<0.001) in ALP activity in serum and salivawhile significant increase (p<0.05) in specific activity of ALP for serum and saliva in both (male and female), and anon-significant decrease ALB Level (p>0.05) in serum and saliva in patients with gingivitis. The levels of serum andsaliva testosterone were significantly decrease (p<0.05) in gingivitis than healthy group. While estradiol level washighly significant increase (p<0.001) in saliva and serum gingivitis patients in compared to the healthy group. Theresults of studying the correlation between the above parameters indicated there were a highly significant positivecorrelation obtained is between sera E2 with (ALP, IL-6,) and between sera testosterone with (ALP, IL-6), and betweensaliva testosterone with albumin .while negative correlation between sera E2 with ALB, and between saliva E2 with allthree inflammation marker (i.e. ALP, albumin and IL-6), also negative association was found between seratestosterone with ALB and between salivary testosterone with (ALP and IL-6).Conclusion: the results generated from this study could lead to improvement in gum care program for peoples andrevealed an association between gingivitis progression with hormonal changes production as result to increase theinflammation marker (ie IL-6, ALP).Also saliva analysis is better for determination the free bioavailable steroid hormones than sera analysis