Detection of Latent Autoimmune Diabetes of Adults among Type 2 Diabetic Patients Using Glutamic Acid Decarboxylase Antibodies

Abstract

Background: Latent autoimmune diabetes of adults (LADA) is a slowly progressive form of autoimmune diabetes initially managed with diet and oral hypoglycemic agents before becoming insulin requiring. GADA are used for differential diagnosis between LADA and type 2 diabetes.Objectives: To assess the prevalence of LADA among type 2 diabetic patients using glutamic acid decarboxylase (GAD) antibodies.Methods: Cross sectional study conducted on 100 patients with primary diagnosis of T2DM, 52 female and 48 male, aged 30-70 years. The GADA test is used for diagnosis of LADA patients. Results: Out of 100 patients with primary diagnosis of T2DM , 14 patients (14%) were positive for GADA. Conclusions: LADA patients accounts for 14% of T2DM using GADA assay. Age, sex, and BMI had no significant effect on the prevalence of LADA patients among T2DM.

Keywords

GADA, LADA, T2DM