Study of Some Cytokines and Hormones in a Sample of Iraqi women with Polycystic ovarian syndrome and Their Relation to Obesity.

Abstract

Abstract:The present study aimed to measure serum vaspin and apelin levels in women withPCOS to show their rule in the pathogenesis of PCOS. Ninety eight women with PCOS, 51non-obese [body mass index (BMI) less than 25 kg/m2] and 47 obese (BMI >25 kg/m2) wereenrolled in the study. Each group is compared to apparently healthy women as a control groupmatched for age and BMI. Clinical history, anthropometric measurements and biochemicaland hormonal analysis were determined. The mean serum level of vaspin and apelin showedstatistically significant difference between PCOS patients (non-obese and obese) compared tocontrol women (non-obese and obese) respectively. Also, the levels of both parameters(vaspin, apelin)showed significant differences between PCOS obese patients and non-obeseones. It is concluded that serum vaspin and apelin level increased in PCOS womenparticularly the obese. These data suggest their involvement in the pathogenesis of PCOSKey word: Polycystic ovary syndrome, vaspin, apelin.