تأثير مستخلصي عرق السوس وثمار الكاكي في تثبيط الأنحرافات الكروموسومية المستحثة بمادة كبريتيت الصوديوم في خلايا الفأر الأبيض

Abstract

Active compounds in Glycyrrhiza glabra and Diospyros kaki fruit were detected .chemical detection revealed that extracts of G.glabra contains glycosides, tannins, alkaloids, saponine, terpins, sterols, flavonoid, and coumarins. While extract of D.kaki contains tannins, saponins, phenols, resins, terpins, sterols and flavonoids.White mice infected with chromosomal aberration induced by sodium sulphate at concentration of 100 mg/kg, injected with extracts at concentrations of 2, 5, 8 mg/kg through intrepretonially.Results showed that all concentrations of the extracts have inhibitory effects on chromosomal aberrations. Inhibition increased at 8 mg/kg which reached 1.6% for chromosome Breaks and 2.0% for chromatid breaks in sexual cells, and reached 2.3% for chromosome Breaks and 4.1% for chromatid breaks in bone marrow cells for G.glabra extracts .percentages of inhibition using D.kaki fruit extract were 1.0% for chromosome Breaks and 1.8% for chromatid breaks in sexual cells while in bone marrow cells were 2.0% for chromosome Breaks and 3.3% for chromatid breaks. The differences were significant when the results compared with positive control .interaction between the two extracts showed inhibitory effects which increased at concentration 8 mg/kg.