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Article
The correlation between thyroid hormones, reproductive hormones, body mass index (BMI) and hirsute in Iraqi women with polycystic ovary syndrome (PCOS).
العلاقة بين هرمونات الدرقية والتكاثر وكتلة الجسم و المشعرانية عند النساء العراقيات المصابات بمتلازمة تعدد الاكياس المبيضية.

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Abstract

This research was conducted to study the relationship between the polycystic ovarysyndrome (PCOS) and thyroid disorders. The study includes 50 infertile Iraqi women with polycystic ovary syndrome (PCOS) and 20 healthy women. Blood samples were collected from the Infertility Center of AL-Yarmok Teaching Hospital in Baghdad, during the period from November, 2010 to May, 2011. The age of infertile and fertile women was ranged from 16 to 45 years. Hormonal study of Estradiol (E2), Luteinizing hormone (LH), Follicle stimulating hormone (FSH), Testosterone (T),Thyroid stimulating hormone (TSH) , Triiodothyronine (T3) and Thyroxin(T4) was done for each patient. The results showed that there is a significant (P <0.05) decrease in E2 and FSH levels in PCOS women comparing with fertile women. Also a significant (P <0.05) increase in LHFSH was detected in PCOS women and fertile women and non-significant (P <0.05) differences in testosterone,TSH,T3 and T4 levels between infertile and fertile women.The hormonal profile according to Body mass index -BMI was showed to be significantly (P <0.05) decreased in testosterone in obese and overweight PCOS women, significant (P <0.05) decrease in FSH level in obese PCOS women and no significant differences in E2 and LH levels.According to the hirsute in PCOS women the hormonal profile showed a significant (P <0.05) decrease in E2 and FSH levels in hirsute PCOS women, no significant differences in LH levels and elevated in testosterone levels but without significance in hirsute PCOS

هدفت الدراسة الى أيجاد العلاقة بين متلازمة تعدد الاكياس المبيضية و أختلال الهرمونات الدرقية. شملت الدراسة 50 من النساء غير الخصيبات مصابات بمتلازمة تعدد الاكياس المبيضية و 20 من النساء الخصيبات الطبيعيات. جمعت عينات الدم من المشمولات بالدراسة من مركز العقم في مستشفى اليرموك التعليمي في بغداد بين نوفمبر 2010 الى مي 2011. تراوح عمر المشمولات بالدراسة بين 16 و 45 سنة. حسب مستوى هرمونات الاسترادول و هرمونات التكاثر LH, FSH و التستوستيرون و هرمونات الدرقية T3,T4 و الهرمون المحفز TSH لهما ولجميع المشمولات بالدراسة. بينت النتائج وجود أنخفاض معنوي بأحتمالية 0.05 في مستوى هرموناتالاسترادول و FSHوزيادةمعنويةفيمستوىLHFSHعند النساء المريضات مقارنة مع الطبيعيات.كما بينت النتائج عدم وجود فروق معنوية في مستويات هرمونات التستوستيرون و الهرمونات الدرقية T3, T4و TSH بين النساء المريضات و الطبيعيات. قياس مقدار كتلة الجسم BMI و المشعرانية تم أيضا في هذه الدراسة. بينت النتائج وجود انخفاض معنوي في مستوى التستوستيرون في النساء المريضات بمتلازمة تعدد الاكياس المبيضية والسمينات و زائدات الوزن و انخفاض معنوي في مستوى هرمون FSH و عدم وجود فروق معنوية في مستوى هرمونات الاسترادول و LH في المريضات السمينات. وبينت نتائج المشعرانية ان هناك انخفاض معنوي في مستوى هرمونات الاسترادول و FSH و عدم وجود فروق معنوية في مستوى هرمون LH و أرتفاع غير معنوي في مستوى التستوستيرون عند النساء المشعرات المريضات بالمتلازمة.


Article
The Chages in Sex Hormones in Female Working in Battries Manufacturing Plant

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Abstract

Lead has toxic effects on reproduction of both male and female. It can cause decreased sex drive , infertility and abnormal menstrual cycle in women. This study was designed to evaluate the effect of exposure to lead in batteries female workers on sex hormones level in the serum.Thirty nine (39) female workers (volunteers) in Iraqi Batteries Manufacturing Plants, Al-Waziriya / Baghdad were participated in this study. They are classified into 3 groups, first group included fourteen (14) female that have been employed for 1-7 years , second group included thirteen (13) female that have been employed for 8-14 years , third group included twelve (12) female have been employed for15-22 years and and fourteen females were included as the control . Blood lead level, serum FSH, LH, prolactin and total testosterone were measured and compared for all subjects.The results indicated that mean of blood lead levels (BLL), testosterone levels were highly significant in all worker groups compared to the control (p<0.005).Prolactin levels in group I and FSH in group III were significantly higher than that in control ( P< 0.005) and (P<0.05) respectively. LH levels in groups II and III were significantly higher than that in control (P<0.05, P<0.005 respectively). High incidence of hirsutism (48%) and miscarriages (50%) were observed in worker groups compared to control (11%). The results indicated that there are hormonal changes in female workers exposed to lead associated with increased incidence of hirsutism and miscarriages compared to non exposed females .

تسعة وثلاثون امرأة عاملة في معمل صناعة البطاريات في بغداد شاركن في هذه الدراسة كمتطوعات قسمت العاملات الى ثلاث مجاميع اعتمادا على فترة التعرض للرصاص.١-المجموعة الأولى تشمل (١٤) عاملة وفترة الخدمة تتراوح بين (١ـ٧) سنوات وبعمر (٢٤ـ٥٠) سنة.٢ـ المجموعة الثانية تشمل (١٣) عاملة وفترة الخدمة تتراوح بين (٨ـ١٤) سنة وبعمر (٣٠ـ٥٥) سنة ٣ـ المجموعة الثتلثة تشمل (١٢) عاملة وفترة الخدمة تتراوح بين (١٥ـ٢٢) سنة وبعمر (٣٢ـ٥٢) سنة.٤-المجموعة الرابعة: مجموعة السيطرة وتشمل (١٤) امرأة بمتوسط عمر( ٢٩±١.٧) سنة.وجد في هذه الدراسة ان هنالك تغير في مستوى الهرمونات الجنسية عند النساء العاملات عند مقارنتها بمجموعة السيطرة.وجد كذلك ان مستوى الهورمون اللوتيني في المصل يزداد عند العاملات اللواتي تعرضن للرصاص لفترة طويلة اما هورمون محفز الجريب في المصل يزداد فقط عند النعرض لفترة طويلة.اما هورمون (البرولاكتين ) فيزداد فقط بعد التعرض لفترة قصيرة للرصاص.كذلك هورمون التيستوستيرون الكلي يزداد عند النساء العاملات متصاحبا مع زيادة في نسبة الشعرانية والاسقاطات عند العاملات مقارنة بمجموعة السيطرة.


Article
DIGITAL DERMATOGLYPHIC CHARACTERISTICS IN PATIENTS WITH SEX HORMONES ANOMALIES

Authors: Rakad M. Kh. Al-Jumaily --- Fadhel M. Lafta --- Lamees Kh.I. Al-Dahiri --- Laith Z.Fadhil
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2010 Volume: 13 Issue: 2 Pages: 164-169
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background : Dermatoglyphics are the dermal ridge configurations on digits ,palms and soles.Dermatoglyphic polymorphism results from the interaction of genetic and environmental factors.The dermatoglyphic analysis is a valuable completion of initial diagnosis of some syndromes anddiseases that are genetically determined. Our objective was to assess the relationship betweendigital dermatoglyphic patterns and sex hormones anomalies.Methods : Dermatoglyphic pattern type frequencies (qualitative analysis ), total and absolute ridgecounts (quantitative analysis )and left /right asymmetry were assessed for 54 males with sexhormones anomalies and 55 controls .Results : Dermatoglyphics pattern type frequencies were altered in patients with sexhormones anomalies versus controls . In particular, there was an increase and decrease of whorls(38.2% vs. 33.5%) and ulnar loops (51.7% vs. 58.5%) respectively. The differences weresignificant ( χ2 = 10.335 ; D.F. = 3 ; P ≤0.05 ) .In quantitative analysis , patients showeda higher mean ridges count than controls in both; the TRC (159.81 } 5.46 vs. 144.61 } 5.84 ) andARC (213.72 } 11.19 vs. 187.96 } 11.07 ) respectively ,and a significant difference was observedin TRC analysis (t = 1.899 ; d.f. = 107 ; p = 0.06 ). Among patients with sex hormones anomalies44.44% of them had a higher ridge counts on the left hand than on right hand versus 38% incontrols .Conclusion: Our results supported the hypothesis that prenatal sex hormones levels may have asignificant effect on the development of dermatoglyphics.

الخلفية العلمية : يعنى علم الخطوط الجلدية بدراسة أشكالالخطوط الجلدية في البنان ، راحة الكف وباطن القدم .و إنتعدد أشكال الخطوط الجلدية هو نتاج لتظافر عوامل الوراثةوالبيئة . كما أن تحليل صفات الخطوط الجلدية قد أصبح ذوقيمة في التشخيص الأولي لبعض المتلازمات والأمراضالوراثية .وقد هدف بحثنا إلى تقييم العلاقة بين أنماطالخطوط الجلدية للبنان واضطراب الهورمونات الجنسية .العمل: تم حساب تكرار أنماط الخطوط الجلدية ( التحليلالوصفي ) ، وعدد الخطوط الجلدية الكلي والمطلق( التحليل الكمي ) وعدم التناظر لعدد الخطوط ل 54 ذكراًيعانون من اضطراب الهورمونات الجنسية و 55 فرداًيمثلون مجموعة السيطرة .النتائج : اظهر مرضى اضطراب الهورمونات الجنسيةاختلافا في تكرار انماط الخطوط الجلدية مقارنة بمجموعةالسيطرة ، وخاصة زيادة المستديرات ( 38.2 % مقابل%33.5 ) ونقصان العرويات الزندية ( 51.7 % مقابل%58.5 ) ، وقد وصل الاختلاف الى المتسوى المعنوي: (قيمة مربع كاي = 10.335 : درجة الحرية = 3. ( الاحتمالية 0.05أما بالنسبة للتحليل الكمي فقد اظهر المرضى زيادة فيمعدل عدد الخطوط الجلدية مقارنة بمجموعة السيطرة ،5.46 مقابل ± بالنسبة لمعدل عدد الخطوط الكلي ( 159.815.84 ± 144.61 ) وكذلك لمعدل عدد الخطوط المطلق11.07 ). وكان ± 11.19 ± 213.72 مقابل 187.96 )الاختلاف معنوياً بالنسبة لمعدل العدد الكلي للخطوطكما ظهر بأن . (t = 1.899 ; d.f. = 107 ;p = 0.06)%44.44 من المرضى يحملون عدداً اكبر من الخطوط فياليد اليسرى مقابل 38 % من مجموعة السيطرة .الاستنتاج : نتائج بحثنا تدعم الافتراض العلمي بأنمستويات الهورمونات قبل الولادة تمتلك تأثيراً معنوياً علىتكوين الخطوط الجلدية .


Article
Study the Effect of Sex Hormones in Diabetic Women

Author: Aufaira shaker nsaif عفيرة شاكر نصيف
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2014 Volume: 27 Issue: 1 Pages: 18-20
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Objectives: The purpose of our study was to investigate the association of C-peptide and steroid hormones (progesterone and testosterone) and type 2 diabetes in diabetic women under 42 years age.Materials and Methods: Thirty, type 2 diabetic women under 42 years old (35-42) years and 30 non diabetic women as control were investigated in this study, age and sex matched. Sex hormones (progesterone and testosterone) were measured by using minividas (Biomerieux). Also serum C-peptide was measured by using gamma counter (Wallac) and fasting blood sugar by using spectrophotometer. All measurements were done in the National Diabetes Center (NDC) / Al-Mustansiriya University, Baghdad - Iraq.Results: the progesterone, testosterone, FBS and C-peptide of diabetic women were 2.963±1.29 pmol/l, 0.150±300 pmol/l, 132.53±9.69 mg/l and 4.25±1.16 ng/l respectively; while the control healthy women were 2.865±0.988 pmol/l, 0.295±0.196 pmol/l, 87.45±7.53 mg/l and 3.76±0.49 ng/l respectively. Differences between diabetic and control women for the testosterone, FBS and C-peptide were statistically significant and for the progesterone were statistically insignificant. Conclusion: There is a strong association between the sex hormones and type 2 diabetes mellitus. Key words: sex hormones, diabetes

Keywords

sex hormones --- diabetes


Article
Physiological and histological effects of (zinc and iron) oxide nanoparticles on some fertility parameters in female mice

Authors: Shaima R.Ibraheem --- Muntaha R. Ibrahim
Journal: Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية ISSN: 1814635X Year: 2016 Volume: 27 Issue: 5 Pages: 1-10
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Nowadays nanoparticles have widespread application in various industries because of their special and unique features, there are many studies in side effects of nanomaterial. This study done by 40 white female mice with every other day intraperitoneally injection of low and high doses of both of ZnO nanoparticles (20 and 150 μg/kg of body weight) and FeO nanoparticles (5 and 40 mg/kg). After a 15 days period, the mice were sacrificed and blood samples were collected for hormone analysis, and tissue samples for morphometric studies.Statistical Analysis shows significant differences in LH, Estrogen, Progesterone hormone levels between groups, while there are insignificant differences in Follicle stimulating hormone (FSH) level between the groups compared with its level in the control group.The results also show that the highest level of LH reach 7.2 mIU/ml in the groups treated with low dose of zinc oxide, the highest level of FSH reach 4.58 mIU/ml in the groups treated with low dose of zinc oxide, the highest level of Estrogen hormone reach 69.5 ng/ml in the groups treated with low of dose zinc oxide and the highest level of Progesterone reach 1.9 ng/ml in the groups treated with high dose iron oxide. We conclude from the results that the low doses of ZnO has benefits in increasing fertility through high level of reproductive hormones, while the high levels of nanoparticles reduce fertility and there is a relation between FeO nanoparticles and progesterone levels which may need more future studies.Morphometric study of the ovary show increase in Follicular stages number range in the group treated with Low dose ZnO in compare with its range in the control groups. The lower range was belong to the group treated with the high dose of FeO. No significant differences has been found in the diameter mean of the different follicular phases between the group treated with low dose of ZnO NPs in compared with the control group. High dose of ZnO NPs cause significant increase in the diameter mean of Primordial follicles in compared with the control group. Low and high dose FeO NPs treated groups show significant reduction in the diameter mean of the different follicular phases in compared with the control group.

Keywords

Nanoparticles --- fertility --- hormones --- mice.


Article
Effect of sex hormones level on the external genital tract infection in pregnant and non- pregnant women in Dhi Qar governorate, Iraq

Authors: Safa Abdul wehab wajeh صفا عبد الوهاب وجيه --- Basim Abdul Hussein باسم عبد الحسين --- Mohanad Abdul Razzaq مهند عبد الرزاق
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2018 Volume: 6 Issue: 4 Pages: 9-17
Publisher: Thi-Qar University جامعة ذي قار

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The current study was conducted in Dhi Qar governorate, Iraq to determine the main types of microorganisms that cause female genital tract infection and the extent of the effect of the level of sex hormones (prolactin, progesterone, estrogen) on the presence of infection , 245 samples were collected for both vaginal swabs and blood (where take a vaginal swab and blood from every woman) , where 150 women were pregnant and 95 women non-pregnant women , aged 16-45 years . Among non-pregnant women, most were women who had a reproductive tract infection within the leuteal phases , where our study included 58 women at leuteal phase , 20 women were in follicular phase , 17 women within ovulation phase of the menstrual cycle .The study showed that Candida albicans , Staphylococcus aureus , Escherichia coli , Gardnerella vaginalis , Klebsiella pneumonia , Staphylococcus epidermids , Enterobacter cloaceae were isolated from women in follicular phase , the diversity of infections was lower in women in the ovulation stage, where they were isolated only Candida albicans , Staphylococcus aureus , Escherichia coli , Gardnerella vaginalis ,and from women with leuteal phase was obtained Candida albicans , Staphylococcus aureus , Escherichia col ,Gardnerella vaginalis , Klebsiella pneumonia , Staphylococcus epidermids , Proteus mirabilis, Pseudomonas aeruginosa , the precence of all type of pathogens in our study was associated with elevated estrogen and progesterone levels except the growth of Staphylococcus epidermids , Proteus mirabilis, Pseudomonas aeruginosa , Enterobacter cloaceae was associated with normal range of each hormones,as for the prolactin hormone did not have a clear effect as the levels ranged between natural and high for all women in the three phases. Pregnancy was accompanied by high levels of estrogen, progesterone and prolactin hormones, this is accompanied with existence Candida albicans , Staphylococcus aureus , Escherichia coli , Gardnerella vaginalis , Klebsiella pneumonia , Streptococcus agalactiae , Trichomonas vaginalis.


Article
Etiology of infertility in couples attending maternity hospital in Erbil
مسببات العقم عند الأزواج الذين يذهبون إلى مستشفى الولادة في أربيل

Authors: Khanzad Hadi Rashid --- Aza Bahadeen Taha
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2013 Volume: 17 Issue: 1 Pages: 322-330
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Infertility remains a global health challenge with devastating psycho-social consequences in many communities and an underlying long-term risk for separation of the couple, also remains a major clinical and social problem. Infertility is defined as inability of a couple to conceive naturally after one year of intercourse. An understanding of the medical causes of infertility is crucial in order to reduce incidences of infertility and for improving the clinical management of infertility. The aim of the study was to determine the causes of infertility in couples. Methods: A retrospective study was done in IVF Unit at Maternity Teaching Hospital in Erbil. Data of infertile couples were collected from already prepared patient’s files. Results: The frequency of primary and secondary infertility among women was 62.97% and 37.03%, respectively. Among 370 couples, 35.68% had female factor, 29.46% had both male and female factors, and 19.73% had male factor, while 15.14% of the couples had unexplained infertility. Conclusion: Primary infertility was common health problem in couples, also the causes of infertility in women is noticed more than men.

Keywords

Infertility --- Etiology --- Hormones --- Semen


Article
4.REPRODUCTIVE HORMONAL ASSAY OF A SAMPLE OF IRAQI OBESE MALES

Authors: Imad M. Abdul-Rahman عماد محمود عبد الرحمن --- Atheer J. Abdul-Ameer اثير جواد عبد الامير
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2019 Volume: 17 Issue: 2 Pages: 114-119
Publisher: Al-Nahrain University جامعة النهرين

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Background:The World Health Organization considered obesity as a medical condition that may lead to reduced life expectancy and/or increased health problems. While much of the focus on the impairments caused by obesity is on somatic health, recent data suggest that reproductive health may also be impacted.Objective:To quantify the relation between obesity and the reproductive hormones.Methods:This cross-sectional study was carried out at nutrition clinic in three teaching hospitals and one obesity clinic in a medical college in Baghdad. The body mass index (BMI) calculation, blood sugar, serum cholesterol, triglyceride, testosterone, prolactin, follicular stimulating hormone (FSH), and luteinizing hormone (LH) were measured.Results:Ninety-five adult obese males participated in this study. Serum testosterone had significant negative correlation with BMI, weight, serum cholesterol, and serum triglyceride while serum LH had significant positive correlation with BMI (p value was 0.013), weight (p value was 0.027), and serum triglyceride (p value was 0.049).Conclusion:Male obesity has significant effect on serum level of testosterone and LH.Keywords:Obesity, reproductive hormonesCitation:Abdul-Rahman IM., Abdul-Ameer AJ. Reproductive hormonal assay of a sample of Iraqi obese males. Iraqi JMS. 2019; 17(2): 114-119. doi: 10.22578/IJMS.17.2.4


Article
The Effect of Chronic Renal Failure on Thyroid Hormones

Author: Layla K. Ali
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2010 Volume: 19 Issue: 1 Pages: 65-68
Publisher: Baghdad University جامعة بغداد

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Chronic renal failure (CRF) affects thyroid function in multiple ways, including low circulating thyroid hormone concentration, altered peripheral hormone metabolism, disturbed binding to carrier proteins, possible reduction in tissue thyroid hormone content, and increased iodine store in thyroid glands.The target of study is to find a relationship between chronic renal failure and thyroid function.In addition, we tried to study the effect of CRF on serum creatinine dependent on the level of thyroid hormones (T3 and T4) and thyroid stimulating hormones(TSH). Forty patients with chronic renal failure (20 male, 20 female) were enrolled in this study in addition to forty healthy individual as control group (20 male, 20 female). The age ranged from (25 -65) years. T4, T3, TSH, urea, uric acid and creatinine were measured in each of the two groups. The results revealed statistically significant reduction in T3 and T4 while there is elevation in TSH, urea,uric acid and creatinine in the patients group compared to the control group.

يؤثر القصور الكلوي المزمن على فعالية الهرمونات الدرقية بطرق متعددة تتضمن قلة في تركيز هرمون الغدة الدرقية في الدم، تبدل أو تغير ايض الهرمون في الانسجة المحيطية، وإرتباطه بالبروتين الناقل، أحتمالية انخفاض مستوى الهرمونات الدرقية في الانسجة المحيطية والبلازما وكذلك زيادة خزن اليود في الغدة الدرقية. الهدف من الدراسة ايجاد علاقة بين القصورالكلوي المزمن والغدة الدرقية بالاضافة الى دراسة تاثير الفشل الكلوي المزمن اعتمادا على مستويات الهرمونات الدرقية والهرمون المحفز للدرقية. جمعت النمادج من 40 مريضا" مصابا" بالفشل الكلوي بالاضافة الى 40 شخصا" من الاصحاء كمجموعة سيطرة.اعمار المجاميع تتراوح بين (25- 65) سنة . تم قياس هرمونات الغدة الدرقية (ثلاثي يوديد الثايرونين والثايروكسين) ،الهرمون المحفز للدرقية،اليوريا ، حامض اليوريك والكرياتنين .بينت النتائج وجود انخفاض معنوي في كل من ثلاثي يوديد الثايرونين والثايروكسين في حين وجد ارتفاع ملحوظ في كل من الهرمون المحفز للدرقية ،اليوريا، حامض اليوريك والكرياتنين في مرضى القصور الكلوي مقارنة بالاصحاء.


Article
Lipoxidative and Glycoxidative Modifications of Erythrocytes-Proteins in Relation to Thyroid Status
التبدلات في تفاعلات اكسدة الدهون واكاسيد السكر مع بروتينات كريات الدم الحمر وعلاقتها بنشاط الغدة الدرقية

Author: Shatha Hussein Ali د.شذى حسين علي خضر
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2005 Volume: 18 Issue: 2 Pages: 191-196
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract :Objective : Different mechanisms for lipid peroxidation activation in patients presenting with thyroid hormone abundance or deficiency have been analyzed . However, changes in metabolism associated with thyroid dysfunction through the glycoxidative reactions and its contribution to such enhancement of lipid preoxidation is assessed in this study. Methods:The study included seventy –two patient with either , hyperthyroidism , hypothyroidism or euthyroidism, in addition to 25 control subjects for the estimation in their erythrocytes :-1-concentration of the end product of lipid peroxidation (malondialdehyde- MDA).2-susceptibility to oxidative challenge (H2O2- induced methaemoglobin- Met-Hb).3-glycosylation of proteins (glycated haemoglobin- GHb).Results : The hyperthyroid patients group were presented with significantly elevated MDA levels (p < 0.001) among other thyroid disorders. Elevated Met-Hb levels were detected in different thyroid diseases. Moreover, significant modulation of glycated haemoglobin values was observed in both hyper- and hypothyroid patients (7.8 ± 1.8 , 5.9 ± 1.7 , respectively Vs control 5.1± 0.82).Conclusion : The changes in lipoxidative and glycoxidative modification of proteins in patients with thyroid pathology may have some clinical and biological implications. Key words : thyroid hormones , MDA, Glycated- Hb

ملخص:هناك فرضيات عديدة لتفسير اسباب زيادة سرعة اكسدة الدهون في الحالات المرضية المصاحبة لزيادة او نقصان نشاط الغدة الدرقية موضوعة حاليا قيد البحث . احتمال وجود علاقة للتغيرات الحاصلة في الايض المرتبطة بنشاط الغدة الدرقية بالتغيرات في ايض السكر وبالتالي امكانية مساهمته في تفسير زيادة اكسدة الدهون. تضمنت الدراسة الحالية اثنان وسبعون مريضا بين مصاب بزيادة او نقصان او اعتدال في نشاط الغدة الدرقية ، اضافة الى 25 شخصا طبيعيا كمجموعة مقارنة وذلك لغرض دراسة :1-تراكيز اكاسيد الدهون (المالوندايلديهايد) في كريات الدم الحمر .2-القابيلة للاكسدة بمادة بيروكسيد الهيدروجين لتكوين الميتوهيموكلوبين.3-تركيز البروتينات المتفاعلة مع السكر.اظهرت نتائج الدراسة زيادة نسبة المالوندايلديهايد في كريات الدم الحمر لمرضى فعالية الغدة الدرقية الزائدة وكذلك زيادة في تكوين الميتهيموغلوبين يصاحب الانواع المختلفة من الاختلال في وظائف الغدة الدرقية ، مع زيادة ملحوظة في درجة تفاعلات السكريات مع بروتينات كريات الدم الحمر في حالتي زيادة ونقصان نشاط الغدة الدرقية .يمكن الاستنتاج من هذه النتائج ان هناك تغيرات في تفاعلات اكسدة الدهون واكاسيد السكر مع بروتينات كريات الدم الحمر في الامراض المصاحبة لأختلال نشاط الغدة الدرقية والتي قد يكون لها بعض التطبيقات السريرية والحيوية لتحسين حالة المريض.

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