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Oocyte Quality and Embryonic Development after Oral Administration of Speramax® in Female Mice as Experimental Model for Mammals

Authors: Saad S. Al-Dujaily --- Hiba S. Hamza
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2014 Volume: 4 Issue: 2 Pages: 6-13
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Speramax® was found to play an important role in sperm function characters andmales reproductive performance with no studies on its effects on the oocytematuration and embryonic development in females.Objective:The goal of the present work was to examine the effect of Speramax ® onoocyte maturation ,ova quality , embryonic development and live birth usingmice as a model for mammals .Materials and Methods:In this study, Speramax ® was administrated orally for 1, 2 and 4 weeks . Onehundred and ten female mice were randomly divided into four groups , the firstgroup was superovulated(SUO) while the second group was treated by Speramax®with SUO and the third group was spontaneously ovulated (SPO) and treated withSperamax ® and the forth group was spontaneously ovulated (SPO ) and served ascontrol group .Another forty- eight female mice were used for the determination ofthe number of live births .Results: The results indicated that treatment with Speramax® showed a positiveeffect on oocytes maturation in vivo. There was a highly significance ( p˂ 0.0001)improvement in the number of mature oocytes following treatment withSperamax® in SPO and SUO mice compared with SPO and SUO mice not treatedwith Speramax® . The percentage of embryonic development after 24 and 48 hoursof mating in treated groups with Speramax® was significantly ( p˂ 0.05) higher thanSPO and SUO mice .The study showed that the quantity and quality of embryosobtained from the treated groups were superior to that of the untreated group .Conclusions:It was concluded that the Speramax® greatly improved oocyte maturation,early embryonic development and embryo grading quality embryos with anincrease in the numbers of mice live births.


Article
Evaluation of Lipids in Serum and Follicular Fluid on Oocyte and Human Embryo Quality after ICSI

Authors: Mustafa H.O. Hussein --- Qays A. M. Al-Khafaji --- Mufedah Ali Jawad --- Mohammad O. Selman --- et al.
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2017 Volume: 7 Issue: 1 Pages: 52-61
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The estimation of oocyte quality in human in vitro fertilization (IVF) is an important point for the embryologists. Oocyte selection and the identification of the best oocytes may help to limit an overproduction of embryos and to improve the results of oocyte cryopreservation programs.The follicular fluid (FF) can be provided easily during oocyte pick-up and known to represents an optimal source for non-invasive biochemical predictors of oocyte quality. However, till now no substance was found to be used as reliable markers of oocyte competence to fertilization, embryo development and pregnancy.Metabolism and ATP levels within the oocyte and adjacent cumulus cells are associated with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism provides a potent source of energy and its importance during oocyte maturation is being increasingly recognised.

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