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Article
Analysis of Human Leukocyte Antigen Classes in Patients with Prostate Cancer and Benign Prostate Hyperplasia

Authors: Abdul Karrim S. AL-Khafaji --- Nidhal Abdul AL Mohymen --- Amer AL Najjaar
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 1 Pages: 98-101
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: Certain HLA alleles are occurring in a higher frequency in individuals with particular diseases than in the general population. METHODS: HLA-typing for class I and class II antigens expressed by cells of 40 patients with prostatic adenocarcinima (CAP) and 48 patients with benign prostatic hyperplasia (BPH), ranged in age between 48-80 years were detected by lymphocytotoxicity test using 16A, 39B, 7CW, 14DR and 4DQ antisera. RESULTS: Patients with BPH showed an increased frequency in HLA DR53, while CAP patients showed an increased frequency in HLA-A33 and HLA DR53 antigens compared to 100 healthy Kidney donor individual as a control. The increase in HLA- antigens frequency was proved by statistical analysis, relative risk (RR) and etiological function (EF) values estimation. CONCLUSION: Possibility in the future, for novel selective immunomodulatory therapeutic strategies which stimulate a clinically significant re-expression of class I protein and associated with CTL responses

Keywords

HLA --- Prostate cancer


Article
Human Leukocyte Antigen-DP in Acute Nonlymphocytic and Acute Lymphoblastic Leukemia

Author: Majid Sakhi Jabir
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 3 Pages: 285-288
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGRAOUND:Acute leukemias are characterized by the elonogenic proliferation of hematopoietic progenitor cells arrested in maturation .Clinical manifestations are related to the infiltration of the bone marrow and other tissues by the leukemic blasts.METHODS:Peripheral blood mononuclear cell (PBMC) from leukemic patients (29)(ANLL),(36)(ALL) and from normal donors(55)were typed for Human leukocyte antigen-DP specificities using microlymphocytotoxicity assay.RESULTS:Results showed frequencies of (DPw) alleles in (ANLL) patients were not significantly different from controls ,exept that in DPw1 was absent .In contrast ,in ALL,frequencies of DPw2 and DPw5 were significantly increased (p< 0.05,relative risk (RR)= 1.95 and p<0.01,RR=4.27,respectively .CONCLUSION:These results ,demonstrate both positive and negative associations between major histocompatibility complex (MHC) gene products which are in only very weak linkage with the rest of HLA ,and (ALL,ANLL) patients.The HLD-DP region could thus contain long sought –after genes influencing susceptibility and resistance to leukemogenesis.

Keywords

ANLL --- ALL --- HLA --- DP-Antigen.


Article
HLA Antigens Among Iraqi Muslims Arabs And Kurds

Authors: Batool M. Mahdi --- Khalida M. Al-Moussawy --- Abdul Wahab A.R. Al-Shaikhly --- Ali H. Ad’hiah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 1 Pages: 94-97
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: The HLA system is a relevant tool in population genetics analysis. From the genetic point of view, the HLA system is of general interest because of the extreme polymorphism of all known HLA loci. The allele and haplotype frequencies have a wide diversity among human population and differ in geographically and racially among populations. Iraq had a high percentage of Muslims people that distributed in two groups (Arab and Kurd). These groups are ancient populations and affected by many settlement in many centuries ago. These ancient settlements had left marks on the genetic structure of the modern Iraqi populations. The later immigrations to other countries were high in later years. The aim of study is to estimate the gene frequency of HLA class I (A, B, Cw) alleles in Iraqi Arab Muslims and Kurd Muslims and determine the genetic differences between them. METHODS: A total of unrelated 1400 Iraqi Arab Muslims (AM) and 705 Kurd Muslims (KM) healthy volunteers and individuals referred to Immunology and Tissue Typing Center in Al-Karamah Teaching Hospital for organ transplantation and Forensic medicine, were examined for HLA polymorphism using complement dependent cytotoxicity test from June-2003 to April-2004. RESULTS: The phenotypes of HLA typing of Iraqi Arab Muslims (AM) and Kurd Muslims (KM) were in agreement with Hardy-Weinberg equilibrium. Regarding HLA class I (A and Cw loci), there was a significant differences between these groups. Lasly, there was no significant difference between them in HLA-B. CONCLUSIONS: This may be due to their inhabitants different area in Iraq, and also due to their different origin as Arab and Kurd races with mild differences due to outbreeding and migration. The effects of invaders and settlements from out side the country and intermixing with them may play an important role in these differences


Article
activation of complements pathways in patients with bachcet's disease

Authors: Ikbal Kh. AL-Joofy اقبال الجوفي --- khalida Al- Mousawy --- raad .K.Muslih --- jassim.Al-Khafaji --- et al.
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2006 Volume: 48 Issue: 2 Pages: 190-193
Publisher: Baghdad University جامعة بغداد

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Article
possible association of HLA class-1 molecules with colorectal cancer in Iraqi patients

Authors: batool H. AL-Ghurabi --- ahmed A. AL-Hassan --- sana'a A.AL-Naseri --- khalida Al- Mousawy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2006 Volume: 48 Issue: 1 Pages: 48-53
Publisher: Baghdad University جامعة بغداد

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