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STUDY OF SOME PHYSIOLOGICAL AND HISTOLOGICAL CHANGES IN MUS MUSCULUS MICE AFTER EXPOSURE TO CHLORPYRPHOS PESTICIDE
دراسة بعض التاثيرات الفسلجية والنسيجية للاعضاء الداخلية للفئران المختبرية بعد تعرضها للمبيد الحشري الكلوروفوس

Author: Majdy F. Majeed AL-Ali Nowfel H. Jassim* مجدي فيصل مجيد * نوفل حمادي جاسم
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2008 Volume: 7 Issue: 2 Pages: 84-96
Publisher: Basrah University جامعة البصرة

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Abstract

The aim of this study to determinate the toxic effect for different concentrations of organphosphorous pesticide called Chlorpyrphous, some histological and physiological features of the internal organs of ( Mus musculus ) mice by oral administration. The experimental mice were oral administration of (0.1mg.kg and 0.2 mg /kg. ) twice weekly during 3 weeks. After 21 day of experiment the (GOT, GPT )enzymes and urea and total protein were estimated . The following organ were taken for histological studies: liver, kidney, lung, stomach, intestine, and testes.The histological studies were carried out on the liver and kidney. The results of this study showed that the oral administration of chloropyrphose in some histological changes in kidney and liver. and elevation in the level of GOT of GPT enzyme also urea and protein.

هدف هذا البحث دراسة التأثير السام للتراكيز المختلفة لمركبات (organophosphrus)وتدعى (chlorpyrphose)ودراسة بعض الخصائص النسيجية والفسلجية للأعضاء الداخلية للفئران بطرق الأعطاء عن طريق الفم.الفئران المختبرية أعطيت جرعة 0.1 mg/kg and 0.2 mg/kg)) مرتين كل اسبوع لمدة ثلاثة اسابيع وبعد 21 يوم نقيس أنزيمات (GOT, GPT) وكذلك اليوريا والبروتين. وعملنا دراسة نسيجية للأعضاء الأخرى مثل الكبد والكلية والرئة والمعدة والأمعاء وكذلك الخصيتين.ونستنتج أن أعطاء (chloropyrphose) عن طريق الفم أحدث تغييرات نسيجية في الكبد والكلية وكذلك في مستوى (GOT,GPT)واليوريا والبروتين.

Keywords

Pesticides --- GOT --- Kidney


Article
Clinical Course of Children and Adolescents with Primary Focal Segmental Glomerulosclerosis and the Predictors of Their Outcome

Author: Faleeha Obaid Hasan
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 4 Pages: 351-357
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:The aim of this retrospective study is to report the clinical course of children and adolescents with primary focal segmental glomerulosclerosis (FSGS), and to study their outcome and to identify the predictors of progression to end stage renal disease (ESRD).PATIENTS AND METHODS:This is a retrospective study of 50 patients with biopsy-proven primary FSGS who were admitted from April 1995 - January 2007, during the study period from May 2005 - June 2007. Clinical, Laboratory and histopathological data were recorded. The median follow-up time of 4.5 year.RESULTS:The commonest age and sex group is male between 1 - 5 year. At presentation all patients had nephrotic-range proteinuria, hypertension was noted in 22 (44%) of patients, microscopic haematuria was detected in 20 (40%) of patients, five patients had evidence of abnormal renal function. The distribution of patients according to steroid responsiveness show that the steroid sensitive patients were 21 (42%), 8 (38.09%) of them were frequent relapsers and 11 (52.38%) of them were steroid dependant and 2 (9.52%) of them developed secondary steroid resistance. But those who had steroid resistance from the start of treatment were 29 (58%) patients. During follow-up 30 (62%) patients had complete remission, 15 patients (30%) developed chronic kidney disease (9 of them stage 5).At the end of follow-up, 24 (80%) of 30 patients with normal renal function had short stature. The univariate analysis identified the presence of hypertension (P=0.0027), heamaturia (P=0.0107) and presence of abnormal renal function (P=0.0001) at presentation, also presence of initial steroid resistance (P=0.0383), resistance to cytotoxic therapy (P=0.0032), capsular adhesions in renal biopsy (P=0.0066), tubular atrophy (P=0.0027), interstitial fibrosis (P=0.0010), all expect to be significant predictors of progression to ESRD.CONCLUSION:Considering the clinical and histological characteristics of studied patients, apparently our results are comparable to other published series. The progression to chronic kidney disease (CKD) occurs in 30% of patients after 5 years follow-up, must of them with ESRD, this is relatively good out come compared to other studies.

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