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Developmental changes in fetal male gonads associated with administration of oral contraceptive pills to their mothers during pregnancy.
التغيرات النمائية في المناسل الذكرية الجنينية المرتبطة بتناول الامهات لحبوب منع الحمل الفموية اثناء فترة الحمل

Authors: باسمة محمد الجبوري --- سعد محمد الندا --- بان ثابت سعيد
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2011 Volume: 1 Issue: 2 Pages: 45-52
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

backgroundThe effects of taking oral contraceptive pills that contain steroid hormones (estrogen and progesterone) during pregnancy on some aspects of fetus and newborn have been previously reviewed.ojectiveThe objectives of this study are to detect toe effect of using different doses of progestin and estrogen (contraceptive pills OCPs) by pregnant female mice on the gonadal development of their male fetuses, and on their pregnancy outcome.materials and methods:Ninety female mice were divided equally into three major groups: two experimental (Gland G2) and control group according to the level of the dose. Administration of OCPs (either 0.034 or 0.068 mg/kg b. wL /d dissolved with 0.1ml distilled water) orally once a day, were started at (he first day of gestation and continued tilt day 14 for the experimental groups Gland G2 respectively. When the female in each experimental and control groups reach day 17 of gestation, 15 animals of each group were sacrificed, whereas the other 15 animate were left to be sacrificed at birth time. Weight and numbers Of fetuses were recorded, in addition, histological study for their testes were done.resultsThe statistical analysis showed a highly significant (P< 0-01) decrease in weights and numbers of I fetuses {males and females}, and highly significant decrease (P< 0,01) in the testes diameter of fetuses belonged to mothers treated with normal and double dose of OCPs at day 17 and at birth time . in addition* fetuses belongs to G2 mothers revealed testicular undescending to its normal position and remained adjacent to the kidneys at the upper part of the abdominal cavity in comparison with control group.conclusionAdministration of steroid hormones orally to pregnant female mice for 14 days causes a highly significant decrease in Ihe weight and number of fetuses at day 17 and at birth time and cause negative effect on the diameter of the fetal testes ."the OCPs can inhibit at its high dose, (he descending of the testes to its normal location al the pelvic cavity and (hen to (he inguinal canal,

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