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Article
The effect of intracrevicular injection of fucose on serum interlukine -1beta and tumor necrosis factor alpha

Authors: Chenar A. Mohammad --- Khlood A. Al-Safi خلود الصافي --- Bakhtiar M. Ahmed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 2 Pages: 125-129
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: α-L-Fucose is a methyl pentose sugar, had the ability to kill bacteria, controlling infection and normalizeimmune function. The objective of this study is to determine the effect of sulcular injection of fucose on rabbitsperiodontium , throughout measuring the level of some proinflammatory cytokine ; interlukine 1beta ( IL-1beta) andtumor necrosis factor ( TNF-alpha) in sera of rabbits before fucose injection and at 3 days after fucose injection.Materials and Methods: The study was carried on using ( 20 ) male rabbits of the same species weighted (1-1.5 kg ) ,the blood samples were collected from hearts of 20 rabbits before fucose injection and consider as( non injectedgroup) , and after 3 days of fucose injection and consider as (fucose injected group) and analyzed fordetermination of the concentration of IL-1ß and TNF-α.Results: The results showed a highly significant decrease in the mean concentration of TNF-α in sera of fucoseinjected group(19.05± 1.166) pg ⁄ml when compared to its mean concentration in non injected group (27.25±7.371)pg ⁄ml ,also a highly significant decrease in the mean concentration of IL-1ß in sera of fucose injected group(34.19 ±3.1)pg ⁄ml as compared to its mean concentration in sera of non injected group (38.86 ±4.565)pg⁄ml.Conclusion: both proinflammatory cytokines were influenced and inhibited by local fucose injection


Article
Effect of orthodontic tooth movement on salivary levels of Interleukin-1beta, Tumor Necrosis Factor-alpha, and Creactive protein

Authors: Noor Saadi --- Nidhal H. Ghaib نضال حسين غايب
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 4 Pages: 120-125
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Orthodontic force is considered to stimulate cells in the periodontium to release many mediators suchas cytokines which play a responsible role for periodontal and alveolar bone remodeling, bone resorption and newbone deposition. Aim of this study was carried out to estimate changes of the (interleukin-one beta, tumor necrosisfactor – alpha and C-reactive protein) levels in unstimulated whole saliva during the leveling stage of orthodontictooth movement.Materials and methods: The sample consisted of thirty adult patients (12 males and 18 females) with ages ranges (19-23) years. Each sample had Class I and Class II malocclusion dental classification and required bilateral extraction oftheir maxillary first premolars, underwent a session of professional oral hygiene and received oral hygiene instructionsbefore and during the period of study, one month later fixed orthodontic appliance were placed in the upper archby using 0.014 nickel titanium arch wire. The unstimulated whole saliva was taken from each sample immediatelybefore placement of the appliance (baseline), and at (after1hour, after one week and after two week) followingplacement of the fixed orthodontic appliance. In addition the plaque index and gingival index were recordedduring the interval periods of this study to assess oral cleanliness. The interleukin – one beta and tumor necrosis factoralphawere determined by enzyme linked immunosorbent assay, while the C-reactive protein was determined bylatex agglutination.Results: The results of the present study found the mean value of both salivary (interleukin-one beta and tumornecrosis factor -alpha) were highest at (after1hour) followed by at (after one week) then at (after two week) thanthe baseline with highly statistical significant differences (P< 0.01) among males, females and total samples, inaddition there were no statistical significant differences between males and females (P>0.05). While the mean valuesof C-reactive protein were higher at (after 1hour) only with highly significant differences (P< 0.01) among femalesand total samples while only significant difference (P<0.05) for males, in addition there were no statistical significantdifferences between males and females. Regarding the correlation between salivary (interleukin – one beta andtumor necrosis factor -alpha), there were positive correlation between them at all periods of study. Moreover therewere positive correlation between salivary (interleukin – one beta and tumor necrosis factor -alpha) and salivary Creactiveprotein. On the other hand there were no association between the salivary (interleukin – one beta andtumor necrosis factor -alpha and C-reactive protein) and clinical parameter (plaque index and gingival index).Conclusion: From this clinical study we conclude that orthodontic force induces increasing the levels of (interleukin –one beta, tumor necrosis factor -alpha, C-reactive protein) in unstimulated whole saliva during orthodontic toothmovement.


Article
The Effect of Vit D3 (1,25 dihydroxy cholicalciferol) on Serum Level of Human Tumor Necrosis Factor Alpha (TNF α) Following Apicoectomy

Authors: Faris E Mohammad --- Tahani A Alsondook --- Attalla F Rejab
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2013 Volume: 13 Issue: 3 Pages: 530-536
Publisher: Mosul University جامعة الموصل

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Abstract

To evaluate the efficacy of Vit D3 on serum level of human TNF α in patients with chronic periapical lesion that intended to undergo apicoectomy and compare the results with a group of placebo control. Materials and Methods: The investigation was carried out on 50 subjects of different age(1645) and sex(27 male,23 female) complain of chronic periapical lesion were divided into two groups ) study and placebo group). Study group consist of 25 subject received Vit D3 ampoule(300000 IU) orally 24 hrs before apicoectomy procedure and placebo group consist of 25 subject received distal water ampoule orally 24 hrs before apicoectomy procedure. Peripheral venous blood samples were collected preoperatively , 3hrs postoperatively and 24 hrs postoperatively from each subject of both group to evaluate serum TNF α level by Enzyme Linked Immunosorbent Assays (ELISA) device. Patients subjectively assessed the strength the post operative pain by using Visual Analogue Scale (VAS). Data were analyzed using paired t-test and A NOVA test. Results: The results showed that the serum TNF α levels were decreased significantly in the study group after 3hrs of surgical procedure to (22.62 ± 4.58 Pg/ml) following Vit D3 treatment comparing with TNF α level pretreatment (28.33 ± 10.16 Pg/ml) whereas the TNF α level were increased from (33.38 ± 23.92 Pg/ml) preoperative to (51.11 ± 9.05 Pg/ml) 3hrs postoperative in placebo group. Serum TNF α level after 24hrs of surgical procedure in study group decreased significantly to( 28.24± 7.35Pg/ml) pg/ml) comparing with the postoperative 24 hrs TNF α of placebo group (66.15 ± 13.02 pg/ml),this indicated that the level of TNF α were increased in placebo group after 3hrs and 24hrs postoperatively in comparison to the same time of opera tion in study group. The number of analgesic tablet (acetaminophen) significantly decreased in study group to (1.24 ± 1.01 ) comparing with placebo group (2.24 ± 1.23). Duration of analgesia post operatively increase significantly to (308.20± 144.43) min in study group compared with placebo group (228.44 ±123.02) min. The intensity of postoperative pain decrease significantly after 8hrs (VAS1), 12 hrs (VAS2) of surgical operation in study group (1.16 ± 2.27), (0.44 ± 0.96) compared with placebo group (2.92 ± 1.87), ( 1.52 ± 1.78) respectively. Conclusion: data indicated that Vit D3 have anti inflammatory effect that can decrease level of TNF α so reduced pain and inflammation after apicoectomy

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