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Oocyte Quality and Embryonic Development after Oral Administration of Speramax® in Female Mice as Experimental Model for Mammals

Authors: Saad S. Al-Dujaily --- Hiba S. Hamza
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2014 Volume: 4 Issue: 2 Pages: 6-13
Publisher: Al-Nahrain University جامعة النهرين


Background:Speramax® was found to play an important role in sperm function characters andmales reproductive performance with no studies on its effects on the oocytematuration and embryonic development in females.Objective:The goal of the present work was to examine the effect of Speramax ® onoocyte maturation ,ova quality , embryonic development and live birth usingmice as a model for mammals .Materials and Methods:In this study, Speramax ® was administrated orally for 1, 2 and 4 weeks . Onehundred and ten female mice were randomly divided into four groups , the firstgroup was superovulated(SUO) while the second group was treated by Speramax®with SUO and the third group was spontaneously ovulated (SPO) and treated withSperamax ® and the forth group was spontaneously ovulated (SPO ) and served ascontrol group .Another forty- eight female mice were used for the determination ofthe number of live births .Results: The results indicated that treatment with Speramax® showed a positiveeffect on oocytes maturation in vivo. There was a highly significance ( p˂ 0.0001)improvement in the number of mature oocytes following treatment withSperamax® in SPO and SUO mice compared with SPO and SUO mice not treatedwith Speramax® . The percentage of embryonic development after 24 and 48 hoursof mating in treated groups with Speramax® was significantly ( p˂ 0.05) higher thanSPO and SUO mice .The study showed that the quantity and quality of embryosobtained from the treated groups were superior to that of the untreated group .Conclusions:It was concluded that the Speramax® greatly improved oocyte maturation,early embryonic development and embryo grading quality embryos with anincrease in the numbers of mice live births.

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