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Article
Study of salivary IgA concentrations, salivary flow rate in patients with β –thalassemia major in Missan Governorate

Authors: Jamal M. Diwan --- Zaheda J. Mohammad
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 3 Pages: 55-57
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Beta-thalassemia major is the most common monogenic known disorder in the Middle East,characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypesranging from severe anemia to clinically asymptomatic Individuals. This study aimed to evaluate salivary flow rateand salivary IgA in β-thalassemia major patients. Since many oral and systemic conditions manifest themselves aschanges in the flow and composition of saliva the dental practitioner is advised to remain up-to-date with this issue.Materials and methods: The study samples consist of (60) subjects, patients group composed of (30) patients with β –thalassemia major, age rang (5-23) years and (30) healthy locking subject of both sexes as control group, with agerange from (5-25) years.Results: Most patients were in the first and second decade of life (90%) this indicate a reduced life expectancy inthose patients, laboratory investigations for salivary IgA concentrations revealed a significant increase in means ofthis marker in compare with control group and this difference is statistically significant, (p= 0.05) at P value ≤0.05.Regarding the salivary flow rate there was a statistically significant decrease in mean of salivary flow rate inpatients group as compared with control group (P= 0.013).Conclusions: Beta-thalassemia major affects salivary flow rate and SIgA concentration


Article
An Assessment of Oral Health in Hypertensive Patients Treated with HMG-CoA Reductase Inhibitors (Statins)

Authors: Amir A. M. Al-Joboury --- Rafil H. Rasheed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 4 Pages: 85-89
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Hypertension is a chronic medical condition in which the blood pressure in the arteries is elevated, it'sclassified as either primary (essential) hypertension or secondary hypertension, and it increases the risk of ischemicheart disease, peripheral vascular disease and other cardiovascular diseases. Several classes of medicationscollectively referred to as antihypertensive drugs like beta blockers, calcium channel blockers, angiotensinconverting enzyme (ACE) inhibitors, angiotensin receptor blockers, renin inhibitors and statins (HMG-CoA) reductaseinhibitor. Statin medication may have some beneficial effects when subjects have dental plaque or signs ofperiodontitis as gingival bleeding. The purpose of this study were to assess the oral health in hypertensive patients aretreated with statins in terms of salivary flow rate, pH and oral health indices.Materials and Methods: Ninety saliva specimens collected from three groups of subjects (thirty healthy patients"control" Group I), thirty hypertensive patients treated with anti-hypertensive medications without taking statins(Group II) and thirty hypertensive patients treated with anti-hypertensive medications with statins (Group III).Unstimulated saliva was collected from each patients and participants for assessment of salivary flow rate andsalivary pH.Results: Salivary flow rate is reduced in Group II and III patients compared with Group I. Significant low salivary flowrate observed in Group III patients (hypertensive treated with statins) compared with Group II (hypertensiveuntreated with statins) and Group I (healthy subjects); The median value of gingival index is significantly higher inGroup II compared with corresponding value in Group I, while it attended a significant low value in Group IIIpatients; There is no significant difference in DMF score between Group I and Group III, while a significant high scoreobserved in Group II compared with Group I ; The percent of carries restoration in patients of Group II is significantlylow compared with corresponding value of Group I . Although the percent of carries restoration in patients ofGroup III is less than corresponding value of Group I but it does not reach significant level.Conclusions: Patients using statins therapy are more likely have an improvement in gingival index, DMF score andcarries restoration. The salivary flow rate is reduced in patients treated with statins medications, statins therapy havea beneficial effect on the oral cavity


Article
Salivary IgA in chronic kidney disease patients undergoing hemodialysis in Missan governorate

Authors: Faris Abid Hatem فارس عبد حاتم --- Zaheda Jassim Mohammad زاهدة جاسم محمد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 2 Pages: 54-57
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic kidney disease is a worldwide health problem, with adverse outcomes of cardiovasculardisease and premature death, can be divided into five stages, depending on how severe the damage is to thekidneys, or the level of decrease in kidney function, the final stage of chronic kidney disease is called end-stagerenal disease, salivary immunoglobulin A is the main immunoglobulin found in mucous secretions, including tears,saliva, colostrum and secretions from the genitourinary tract gastrointestinal tract, prostate and respiratoryepithelium. It is also found in small amounts in blood.This study aimedto measuresalivary flow rate andsalivaryimmunoglobulin Alevels in chronic kidney disease patients on hemodialysis treatment in comparison withhealthy control subjects.Materials and Methods: Ninety (90) subjects were participated in this study; 45 Patients undergoing hemodialysis withchronic kidney diseases; 45 health control subjects. Saliva collected was measured and levels of salivaryimmunoglobulin A were measured by Enzyme Link Immunosorbent Assay (Elisa).Results:The present studyrevealed that the mean value of salivary flow rate in chronic kidney disease patients was(0.34 ± 0.19) ml/min, while for healthy control subjects was (1.02 ± 0.39) ml/min, there wasstatisticallysignificantlydecrease in salivary flow rate ofchronic kidney disease on hemodialysis patients as compared to control healthysubjects.The present study revealed that the (Mean±SD) of the immunoglobulin A in chronic kidney disease patientson hemodialysis (388.81±227.86) μg./ml, while in control group (273.98±155.89) μg./ml, the result revealed statisticallysignificant increase in chronic kidney disease patients on hemodialysis as compared to control subjects.Conclusions: Salivary immunoglobulin (IgA) reflects the functional capacity of the glands. Increased concentrationof this component is usually marker of a poor general condition

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