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Article
Mechanical evaluation of nano hydroxyapatite, chitosan and collagen composite coating compared with nano hydroxyapatite coating on commercially pure titanium dental implants

Authors: Sabreen W. Ibrahim --- Widad A. Al Nakkash
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2017 Volume: 29 Issue: 2 Pages: 42-48
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Dental implants act as infrastructure for fixed restoration to look like as a natural tooth.Osseointegration is a biological events and considered as a base for success of dental implant. The aim of this studyis to evaluate the bond strength between bone and Ti implant coated with mixture of nano hydroxyapatite-chitosancollagencompared with Ti implants coated with nano hydroxyapatite implanted in rabbit tibia, after different periodof implantation time (two and six weeks) by torque removal test.Material and methods: 36 screws of commercially pure titanium; 8mm in length and 3mm diameter , 18 screwscoated with mixture of nano hydroxyapatite-chitosan-collagen and18 screws coated with nano hydroxyapatite bydip coating. Structural characteristics was assessed by scanning electron microscope, and FTIR analysis. The screwswere implanted in 18 healthy adult male New Zeeland rabbits each tibia received one screw, right tibia receivedscrew coated with nano hydroxyapatite while left tibia received screw coated nano hydroxyapatite-chitosancollagencomposite. Removal torque test was done by torque meter to determine the highest torque valuenecessary to remove the implants from tibia bone after different period of time of implantation(2 and 6 weeks).Result: Nano hydroxyapatite-chitosan-collagen composite coating was resulting in higher torque removal value thannano hydroxyapatite coating for two periods of time.Conclusion: Concluded that addition of collagen and chitosan to nano hydroxyapatite was more efficient in rapidbone formation than nano hydroxyapatite only


Article
Optimization of Nano Hydroxyapatite/chitosan Electrophoretic Deposition on 316L Stainless Steel Using Taguchi Design of Experiments

Authors: Mohammed Jasim Kadhim --- Nawal Ezzat Abdullatef --- Makarim Hazim Abdulkareem
Journal: AL-NAHRAIN JOURNAL FOR ENGINEERING SCIENCES مجلة النهرين للعلوم الهندسية ISSN: 25219154 / eISSN 25219162 Year: 2017 Volume: 20 Issue: 5 Pages: 1215-1227
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The aim of this work is to determine the optimum parameters for deposition of chitosan and mixture of chitosan and hydroxyapatite (HA) layers using electrophoretic deposition. The layers were on 316L stainless steel substrate. Taguchi approach was utilized to select the optimum parameters for both layers. The parameters used for deposition chitosan are voltage, time and temperature while the parameters used for HA and chitosan are voltage, time, concentration and temperature. Zeta potential tests were employed to measure the solutions stability. Coating layers were characterized for thickness, porosity and nanoroughness using optical microscopy (OM) and atomic force microscopy (AFM). The results from Taguchi design of experiments demonstrated that the best conditions for deposition of chitosan and HA layers are 50 V, 5 min, 3 g HA/L and 30C. The corresponding thickness, % porosity, nanoroughness and microroughness for optimum conditions were 22 µm, 3.53, 4.48 nm and 3.85 µm respectively.

يهدف البحث الى ايجاد الظروف المثلى لترسيب طبقة طلاء الكايتوزون والهيدروكسي ابتايت على السبيكة الاساس الفولاذ المقاوم للصدا بطريقة الترسيب الكهربائي الكاثودي . حيث تم ترسيب طبقة رقيقة من الكايتوزون فضلا عن استخدامه كمادة رابطة بين دقائق طبقات الهيدروكسيباتايت. استخدم الايثانول مع نسبة 5% ماء مقطركمحلول لعملية الترسيب مع 1% من حامض الخليك لاذابة الكايتوزون. تم استخدام برنامج تاكوجي لغرض اختيار الظروف المثلى لترسب طبقة الكايتوزن وتضمنت المتغيرات: فولتية، زمن الترسيب ، ودرجة حرارة كما استخدمت نفس المتغيرات لترسيب الهيدروكسي ابتايت مع اضافة متغير اخر وهو تركيز المسحوق. تم استخدام المجهر الضوئي (optical microscopy) ومجهرالقوى الذرية (AFM) لدراسة خصائص طبقات الطلاء من سمك ومسامية وخشونة. وقد اظهرت النتائج ان افضل الظروف لترسيب الكايتووزن هي(90 فولت، 11 دقيقة و40 مº ) وكان سمك الطبقة هو8 مايكرون واقضل الظروف للهيدروكسيابتايت هي (50 فولت ، 5 دقيقة ، 3 % هيدروكسيابتايت و30 مº) وكان سمك الطبقة هو 22 مايكرون والمسامية هي 3.53% والخشونة النانوية هي 4.48 نانومتر والخشونة المايكروية هي 3.85.


Article
Outcome of Hydroxyapatite Crystals as Bone graft Subistitute in Benign Lytic Lesions of Bone

Authors: Mohammed Hassan Al-Obaidi --- Hamdullah hadi Al-Baseesee --- Ali Tariq Jassim
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 2 Pages: 330 -340
Publisher: Babylon University جامعة بابل

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Abstract

Benign lytic lesions of bone are commonly treated by curettage and the resulting cavity filled by autogenous bone graft, the donor site morbidity is high in this method. In this study the resulting cavity had been filled by synthetic hydroxyapatite crystals which are used to overcome donor site morbidity of autogenous bone graft. To assess the safety and efficiency of the hydroxyapatite crystals as an alternative for autogenous bone graft in the treatment of benign bone tumors and tumor-like lesions. This is a prospective study included 30 patients (14 males and 16 females) with benign bone tumor who treated by intralesional curettage and the resulting cavity filled by hydroxyapatite crystals. The patient's ages ranged from 4.5 year to 39 year, patients selection according to the inclusion and exclusion criteria. The commonest diagnosis was aneurysmal bone cyst ( 10 ) followed by simple bone cyst (6), giant cell tumor (4), fibrous dysplasia (3), enchondroma (2), chondroablastoma(2), nonossifying fibroma (2), and chondromyxoid fibroma(1). Follow up period range from 12 to 24 months both clinically and radiologically according to Irwin's grading system. Most of the study group had well postoperative recovery. The mean follow up period was 17 months (range 12 -24 months). In most patients operative wound healing proceeded well. For patients with lower limb pathology, the mean time of full weight bearing was 18 weeks (range 12 -22 weeks). Range of movements in near by joints was gradually increased and improved in patients were tumor approximated the joint. According to Irwin's classification, except 3 cases develop complication, all cases were Irwin's stage I incorporation at 6 months follow up. At 12 months follow up 1 case remain Irwin stage I, 14 cases were Irwin stage II and 12 cases were Irwin's stage III plus 3 cases develop complication. There was no rejection of implanted hydroxyapatite crystals and no abnormal hematological or biochemical findings in subsequent follow up. Hydroxyapatite crystals are slowly absorbed by body. Bone ingrowth and bone formation around the hydroxyapatite crystals were well. Hydroxyapatite crystals have great biological safety, good biocompatibility and good bone conduction.


Article
Preparation of the Jaws Damaged Parts from Composite Biopolymers Materials

Authors: Riyam A. Al-husseini --- Nehad A. Saleh --- M. H. Al-Maamori
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2017 Volume: 25 Issue: 2 Pages: 581-575
Publisher: Babylon University جامعة بابل

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Abstract

Composite materials composing of fusing two materials or more are disaccorded in mechanical and physical characteristics, The studied the effect of changing in the reinforcement percentage by Hydroxyapatite Prepared nano world via the size of the nanoscale powder manufacturing manner chemical precipitation and microwave powders were two types their preparations have been from natural sources: the first type of eggshells and the other from the bones of fish in mechanical Properties which include the tensile strength, elastic modulus, elongation, hardness and tear for composite material consisting of Silicone rubber (SIR) reinforced by (µ-n-HA), after strengthening silicone rubber Protect proportions (5,10,15,20 wt%) of Article achieved results that increase the additive lead to increased hardness while tougher and modulus of elasticity decreases with added as shown in the diagrams.

المواد المتراكبة تتكون من خلط مادتين او كثر وتكون مختلفة في الخواص الميكانيكية والفيزيائية , تم دراسة تأثير اضافة هيدروكسي ابتايت كمادة مقواة محضرة بحجم نانوي مايكروي تم تصنيع المسحوق النانوي بطريقة الترسيب الكيميائي والمساحيق المايكروية كانت بنوعين تم تصنيعهما من مصادر طبيعية : النوع الاول من قشور البيض والاخر من عظام الاسماك. على الخصائص الميكانيكية التي تتضمن مقاومة الشد, معامل المرونة, الاستطالة, الصلادة والتمزق للمادة المتراكبة التي تتكون من مطاط السيليكون مدعمة بـ(مايكرو – نانو) هيدروكسي ابتايت, بعد تدعيم مطاط السيليكون بنسب تحميل (5,10,15,20 wt%) من المادة حقق النتائج ان زيادة المادة المضافة تؤدي الى زيادة الصلادة بينما اشد ومعامل المرونة تقل مع الاضافة كما موضح في المخططات.


Article
The In Vitro Release Study Of Ceftazidime drug From Synthesized Strontium Flourapatite And Strontium Hydroxyapatite Coated Particles.
الدراسة المختبرية لاطلاق عقار السفتازديم من جسيمات السترونتيوم فلوراباتيت والسترونتيوم هيدروكسيباتيت المصنعة و المغلفة

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Abstract

Two compounds, strontium flourapatite (SrFA) and strontium hydroxyapatite (SrHA), were synthesized using wet chemical precipitation method. These compounds were characterized by Fourier transform infrared spectroscopy and X-ray diffraction techniques. The morphology and particle size for the resultant particles of the synthesized compounds were checked by scanning electron microscopy. The average particle size of strontium flourapatite was larger than that of strontium hydroxyapatite by 4.55 times. The particles of each compound were coated by trehalose sugar to decrease the possible ionic interactions with these synthesized compounds. An in vitro release study of ceftazidime antibiotic from the strontium flourapatite and strontium hydroxyapatite was performed in a simulated body fluid at a temperature of 37 oC. This release was studied by UV spectrophotometer at λmax of 258 nm for 12 hours. The results of the release study showed that the release of ceftazidime was faster from strontium flourapatite, but it was higher from strontium hydroxyapatite. The disparity in release rapidity and level was related to the considerable difference in the average particle size for the formed particles of the two synthesized compounds.

تم تصنيع مركبين، السترونتيوم فلوراباتيت والسترونتيوم هيدروكسيباتيت، باستخدام طريقة الترسيب الكيميائي الرطب. اجري التشخيص لهذين المركبين بواسطة تحليل فورييه الطيفي بالأشعة تحت الحمراء وتقنيات حيود الأشعة السينية. لقد تم فحص كل من المظهر الخارجي والحجم للجسيمات الناتجة من المركبات المصنعة بواسطة المسح الضوئي للمجهر الإلكتروني وكان متوسط حجم الجسيمات من مركب السترونتيوم فلوراباتيت أكبر منه من السترونتيوم هيدروكسيباتيت وبنسبة 4,55 مرة. بعد ذلك، تم تغليف جسيمات كل من المركبين بسكر تريهالوز وذلك لتقليل التفاعلات الأيونية المحتملة مع هذه المركبات المصنعة. أجريت دراسة مختبرية لاطلاق المضاد الحيوي "سيفتازيديم" من كل من السترونتيوم فلوراباتيت والسترونتيوم هيدروكسيباتيت في السائل المشابه لسائل الجسم عند درجة حرارة 37 درجة مئوية. لقد تمت دراسة هذا الإطلاق بواسطة طيف الأشعة فوق البنفسجية في اعلى امتصاص "258 نانومتر" لمدة 12 ساعة. أظهرت نتائج دراسة الاطلاق الدوائي بأن اطلاق عقار السيفتازيديم من السترونتيوم فلورباتيت كان أسرع، في حين ان الاطلاق من السترونتيوم هيدروكسيباتيت كان أعلى. كان التفاوت في سرعة الإطلاق ومستواه مرتبطا بالفارق الكبير في متوسط الحجم لجسيمات المركبين.

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