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Eruca sativa and Raphanus sativus Oils Enhance Hepatic and Renal Tissues Regeneration in White Mice

Authors: Amel Mustafa Kamil --- Ala'a Hassan Mirza --- Yasamin Thamer Kadoori --- Shaymaa Jamal Ahmad
Journal: Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية ISSN: 1814635X Year: 2018 Volume: 29 Issue: 4 Pages: 27-37
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Regeneration is a process of tissue repairing in the body, and according to this process the cells of the body are divided into three types; labile, stable and permanent cells. The aims of this study are to evaluate the ability of two herbal seed oils [Eruca sativa and Raphanus sativus] to enhance regeneration and repair in the liver and kidney in the irradiated mice. And to investigate which herbal oil is more effective. Four groups of mice were used in this study. The first three groups were exposed to radiation while the fourth was used as a control. After irradiation the first and second groups were treated with local Eruca sativa and Raphanussativus oils respectively. While the third group used as a control. Then histopathological investigation was done. Results: Histopathological examination in irradiated groups exhibited that both seed oils could induce regeneration in both hepatic and renal tissues but the activity of Raphanus sativus oil was more effective than Eruca sativa especially in renal tissue. Meanwhile, poor regeneration process appeared in the third group [control].In conclusion, both local herbal oils had ability to enhance regeneration in the examined tissues but R. sativus seed oil exerted more activity than E. sativa seed oil.

التجديد هي من العمليات الاصلاحية التي تحدث في أنسجة الجسم, واعتمادا على هذه العملية تنقسم خلايا الجسم الى ثلاثة أنواع: الخلايا القلقة والخلايا المستقرة والخلايا الثابتة. تهدف الدراسة الى تقييم قابلية زيت بذور الجرجير وزيت بذور الفجل في تحفيز عملية التجديد والترميم في الخلايا الكبدية والخلايا الكلوية. والتعرف على اي الزيتين يمتلك كفاءة اكبر من الثاني في تحفيز هذه العملية. طريقة العمل: أستخدمت في هذه الدراسة أربعة مجاميع من الفئران؛ المجاميع الثلاثة الاولى عرضت للاشعاع , في حين المجموعة الرابعة لم تعرض للاشعاع وأستعملت سيطرة للمجاميع الثلاثة الاولى. عوملت المجموعة الاولى بزيت الجرجير وعوملت المجموعة الثانية بزيت الفجل, ثم جمعت العينات النسيجية لغرض الفحص النسيجي حيث اظهر الاخيران كلا الزيتين لديهما القابلية في تحفيز عملية التجديد في نسيجي الكبد والكلية. ولكن اظهر زيت بذور الفجل كفاءة أعلى في تحفيز هذة العملية. نستنتج من هذه الدراسة إن زيتي كلا النبتتين لهما تأثير فعال في عملية الترميم والتجديد التي تحدث في الكلية والكبد ولكن كفاءة زيت الفجل أكبر..


Article
Role of Eruca sativa in prevention of induced nephrocalcinosis in rabbits
دور نبات الجرجير في منع التكلس الكلوي المحدّث في الأرانب

Author: Uday Abdul-Reda Hussein عدي عبد الرضا حسين
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2018 Issue: 14 Pages: 65-73
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: Nephrocalcinosis is a clinical pathologic condition characterized by abnormal deposition of calcium phosphate or calcium oxalate in the renal parenchyma, which can result in impaired kidney function.Aim: This study aimed to evaluate the effect of Eruca sativa aqueous extract in prevention of nephrocalcinosis induced by a large dose of oxalic acid in rabbits. Materials and Methods: Twenty four healthy domestic rabbits were equally allocated into three groups and were distributed into: normal group (without drug), oxalic acid group and Eruca sativa group. Both the first and second groups were received distilled water, while the third group received aqueous extract of Eruca sativa for ten consecutive days. Single high dose of oxalic acid was given to induce nephrocalcinosis in rabbits of the second and third groups (except normal group) after 2 hours from receiving of distilled water and Eruca sativa extract at the first day. Blood samples were collected from all animals for biochemical analysis. Urine analysis and histopathological examination were performed for all rabbits to verify the presence of crystals in urine and renal tissues. Results: Eruca sativa aqueous extract produced highly significant reduction in blood urea nitrogen, serum creatinine , with significant reduction in serum Na+ , and highly significant elevation in serum Ca2+ and serum K+ levels, also it is produced highly significant reduction in the calcium oxalate crystals density in urine and renal tissues when compared with of oxalic acid group. Conclusion: Current study found that the aqueous extract of Eruca sativa effectively prevented the formation and deposition of calcium oxalate crystals in renal tissues, thus preventing the occurrence of nephrocalcinosis.

التكلس الكلوي، حامض الاوكزاليك، فرط أوكسالات البول، مستخلص نبات الجرجير، بلورات أوكسالات الكالسيوم.

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