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Article
Effects of Clomiphene citrate on the histological structure of the Iraqi domestic chicken’s ovaries
تأثير عقار كلوميفين سترات على التركيب النسيج لمبايض الدجاج المحلي العراقي

Author: Hayfaa A Al-Shammary هيفاء عبد علي الشمري
Journal: Univesity of Thi-Qar Journal مجلة جامعة ذي قار العلمية ISSN: 66291818 Year: 2018 Volume: 13 Issue: 3 Pages: 57-69
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

Clomiphene citrate is commonly used to induce ovulation in women. However, the effects of clomiphene citrate on the domestic chikens ovary's have not been fully elucidated. Therefore, we used histological analyses to examine the ovaries of Iraqi domestic chickens administered clomiphene citrate (25 mg/kg of body weight) daily for 30 and 60 days. Our results demonstrated that the ovaries from the hens that were administered clomiphene citrate for 30 and 60 days were not morphologically or histologically distinct. However, compared to the control group, both these groups showed a significant treatment effect on ovarian diameter and the number of follicles (P < 0.05), from the result we can conclusion that the clomophene citrate stimulating the ovalation in domestic chikens .

يستخدام عقار كلوميفين سترات عادة للحث على الإباضة عند النساء. ان تاثير عقار كلوميفين سيترات على مبيايض الدجاج لم توضح تماما.لذلك اجريت هذه الدراسة النسيجية لفحص تاثير عقار كلوميفين سترات بجرعتين (25 ملغم / كغم من وزن الجسم) يوميا لمدة 30 و 60 يوما على التركيب النسيجي للمبايض. أظهرت النتائج عدم وجود اي تاثيرات مرضية نسيجية لمبايض الطيور المعالجة بالجرعتين من عقار كلوميفين سترات لمدة 30 و 60 يوما ، كما وأظهرت النتائج ان هذه الجرع لها تأثيرمعنوي عند مستوى احتمال (P <0.05) على قطر وعدد بصيلات المبيضية .من هذه النتائج نستنتج بأن عقار كلوميفين سترات يحفز التبويض في مبايض الدجاج المحلي


Article
Role of Low-Dose Human Chorionic Gonadotropin Following Clomiphene Citrate in Folliculogenesis and Ovulation in Infertile Women

Authors: Omaima I. Khalaf --- Manal T. Al-Obaidi --- Lubna A. Al-Anbari
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2018 Volume: 8 Issue: 1 Pages: 29-37
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Ovulation disorders, usually presents as menstrual disturbance, arethe cause of infertility in around 25% of couples who have difficulty to conceive.The drug most commonly prescribed for the induction of ovulation is clomiphenecitrate (CC). If the patient does not ovulate after the use of CC, the choice wasto add gonadotropins. Gonadotropin therapy is very expensive with significantrisks of high order multiple gestations and ovarian hyperstimulation syndrome.Human chorionic gonadotropin hCG can function as a surrogate for LH and occupiesLH receptors for more than 24 hours allowing prolonged stimulation alsoit has longer half-life and greater affinity for the LH receptor.Objective: The purpose of this study was to compare the effectiveness of lowdosehuman chorionic gonadotropin (hCG) in the late follicular phase to induceovulation in clomifene citrate resistant patients who had previously failed toovulate on clomiphene citrate (CC) alone.Subjects,Materials and Methods: A total of 71 patients who attend infertilityclinic in the High Institute of Infertility Diagnosis and Assisted ReproductiveTechnologies, Al-Nahrain University, where prospectively randomly assignedinto two groups. hCG Group received 100 mg dose of CC from day 5 of menstrualcycle for 5 days, then each patient received 200 IU hCG (DICLAIR®)subcutaneous injection daily when the largest follicle mean diameter was 12 mmor larger starting on day twelve of menstrual cycle. Non-hCG group received 150mg dose of CC from day 5 of menstrual cycle for 5 days, and both groups weremonitored with transvaginal ultrasound. Ultrasound measurements of folliclenumber and growth, ovulation, endometrial thickness and pattern were recordedand compared between the two groups. Student t test and fisher exact test wereused for statistical comparison between the two groups.Results: The low-dose hCG group had significantly higher percentage of ovulatorycycles (80% vs 44.4% P value 0.006). There was no significant difference inthe endometrial thickness between the groups but it appears higher in hCG group(10.55±1.82 vs. 9.62 ± 1.87 in non-hCG group, p value 0.056). Non significantbut higher incidence of echogenic (luteinized) endometrium 48 hour post ovulationin hCG group (36/40 (90%) vs. 20/25 (80%) for non-hCG group p-value =0.288).Conclusions: The use of low-dose hCG after CC in the late follicular phase resultsin continued follicle growth, higher ovulation rate. This treatment offers anefficient and cost-effective alternative before gonadotropin therapy for this typeof patients.

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