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Psychiatric Squele of Sodium Valproate VersusCarbamazipine in Patients with Primary Generalized Epilepsy

Authors: Hassan Aziz حسان عزيز --- Abdul R Al Yasiri عبد الياسري --- Zaki N. Hasan زكي نوح حسن
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2009 Volume: 5 Issue: 1 Pages: 19-24
Publisher: Baghdad University جامعة بغداد


Background: psychiatric and behavioral side effects are common in patients with epilepsy and it may represent an intrinsic feature of the disease itself or a side effect of the antiepileptic use. Our aim in the present study is to assess the psychiatric side effects of Sodium Valproate and Carbamazipine .as these drugs are the most commonly used antiepileptic drugs in Iraq.Methods: 80 patients with primary generalized epilepsy on Carbamazipine and 50 patients on Sodium Valproate were enrolled in the present study; all the patients were assessed for any psychological disturbances using semi-structural interview based on the tenth edition of the international classification of the diseases(ICD 10) adopted by WHO.Results: thirty percent of patients taking Sodium Valproate and (9%) of patients taking Carbamazipine were found to have depression while (16%) of patients taking Sodium Valproate and (20%) of patients taking Carbamazipine were found to have anxiety. There were no reported psychosis, suicidal attempts, cognitive deficit and mania in both groups of patients in the present study.Discussion: Carbamazipine is associated with lower rates of psychological side effects than Sodium Valproate; this result may be related to mood stabilization effects of Carbamazipine.Conclusion: Carbamazipine is preferred to Sodium Valproate when the efficacy of both drugs is comparable.

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