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Article
Evaluation of Serum Transaminases Levels In Transfused β-Thalssaemia Major Patients

Author: Saad A. Mustafa سعد مصطفى
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 1 Pages: 59-60
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: β-thalassemia major is a genetic disorder characterized by reduced rate of β-globin chain production. Clinically, β-thalassemia major is a severe, transfusion-dependant disorder; repeated blood transfusion will lead eventually to chronic liver disease.Patients and Methods: One hundred patients ; 56 males and 44 females who were known cases with β-thalassemia major on regular blood transfusion, aged between 6 months and 18 years, were studied in a private pathology laboratory, between January 2002-January 2006.Blood was drawn to estimate serum glutamic pyruvate transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT) levels. Results: Sixty-six patients (66%) had elevated SGPT and SGOT levels ranging between two and more than five fold increase than normal.Thirty-four patients (34%) had normal SGPT and SGOT values of less than 40 i.u. /L. The levels of SGPT and SGOT were significantly higher in splenectomised patients than nonsplenectomised.Conclusion: Serum transaminases were elevated in (66%) of transfused patients with B-thalassemia major.Keywords: Serum Transminases, Thalassemia Major, Transfusion-Dependant.


Article
mRNA in situ hybridization analysis of p-53 cancer suppression gene and Bcl-2 oncogene in chronic lymphocytic leukemia

Authors: Saad A. Mustafa --- Haythem A. Al-Rubaie --- Abdulkareem M. Jaafar
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 2 Pages: 177-181
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Several factors render chronic lymphocytic leukemia (CLL) an interesting subject for study by researchers. These include marked progress in understanding the molecular biology of normal and neoplastic lymphocytes and recent advances in molecular genetics techniques. Among molecular markers, p53 cancer suppressor gene and the antiapoptotic gene Bcl-2 have been widely studied. Patients and methods: A retrospective cross-sectional study done on 60 patients with chronic lymphocytic leukemia compared with 20 controls (anemic patients), all recruited at the Medical City Teaching Hospital laboratories from January 2004 to December 2007. The bone marrow biopsy of each was re-examined histologically. In situ hybridization was performed utilizing biotin labeled p53 and Bcl-2 cDNA probes.
Results: The frequency of p53 positive signals in the study group was 28.3% (17of 60 cases). A significantly larger number of patients, with high score for p53 signal, were associated with high-risk clinical stage than patients with low score (p = 0.005). There was a significant direct positive correlation between increasing scores of p53-positive chronic lymphocytic leukemia cells and advancing clinical stage of the disease (p =0.002).
The frequency of Bcl-2 positivity was 50% (30 of 60 cases). No significant correlations found between Bcl-2 scores and clinical stage of the disease.
Conclusion: Although p53 alteration may occur early in the course of the disease, as shown by the p53 positivity in a proportion of patients in low and intermediate-risk stage of the disease, the highest frequency p53-positive cells, has been observed in high-risk stage of the disease. Therefore, p-53 score is an important prognostic variable in patients with chronic lymphocytic leukemia. However, Bcl-2, as assessed by ISH, is not regarded as an important prognostic marker.


Article
The Present of AgricuItual Insurance in IRAQ
واقع خدمات التأمين الزراعي

Author: Saad A. Mustafa سعد عبد الله مصطفى عاصم
Journal: Al-Rafidain University College For Sciences مجلة كلية الرافدين الجامعة للعلوم ISSN: 16816870 Year: 2007 Issue: 21 Pages: 39-60
Publisher: Rafidain University College كلية الرافدين الجامعة

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Abstract

The market of agricultural insurance in Iraq is new. It faced many obstacles such in accurate information and lack of awareness of benefits of insurance , because of their dependence on facilities submitted by the government. Most insurance services are on by National Insurance Companies provied.Granting offsets lacks scientific estimations and un delayed payments.

يمتاز سوق التامين الزراعي في العراق بحداثة العهد إذ تواجه خدمات التامين معوقات عديدة تتمثل في عدم توافر المعلومات الدقيقة وعدم دراية الفلاحين بفوائد التأمين واعتمادهم على الدولة في تدبير المعونات و التسهيلات رغم ذلك كانت معظم خدمات التأمين الزراعي هي لصالح شركة التأمين الوطنية في المجال النقدي أضافه إلى حصول الفلاحين على التعويضات عن الأضرار و الخسائر

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